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Animal Models


 

 

Willi K. Born, PhD - Mouse model of airway hyperresponsiveness

James DeGregori, PhD - Mouse model of pancreatitis induced diabetes and of leukemia development.

Leonard Dragone, MD/PhD -
SLAP deficient mice to study influence of antigen receptor expression on B and T cell development/function.

James Hagman, PhD - Gene targeted and conditional knock-out mice in transcription factor genes that control B cell development and humoral immune responses, including pax5 and ebf1. Transgenic  mice for transcription factor expression and transcription  factor target gene reporters in B cells.

Hua Huang, PhD - Mouse model of airway inflammation and asthma.

Rebecca O'Brien, PhD - Mouse model of autoimmune keratitis

Roberta Pelanda, PhD - Ig knock-in mouse models to study antigen-mediated and tonic BCR signaling in B cell development and selection. BAFF-R Tg mice to study role of BAFF in autoimmunity

Yosef Refaeli, PhD - Mouse models of B-cell Non-Hodgkin's lymphoma, including Burkitt's lymphoma, Follicular-like lymphoma and Diffuse Large B-cell Lymphoma. Mouse models of leukemia, including B-cell chronic lymphocytic leukemia, Acute Myeloid Leukemia and Acute Promyelocytic leukemia.

Jill Slansky, PhD - Mouse models for the study of a self tumor-associated antigen including TCR transgenic, and tumor antigen negative mice.

Raul Torres, PhD - Mouse model for airway inflammation and airway hyperreactivity (asthma) Mouse model for chronic lung inflammation and impaired lung function (emphysema)

Linda van Dyk, PhD - Mouse model of virus induced inflammatory disease manifested in lung and large vessels. Mouse model of virus induced lymphoproliferation and tumors.

Lawrence Wysocki, PhD -
 The Ars/A1 Ig transgenic mouse as a model of regulatory/anergic B cells.  The CA30 abTCR transgenic mouse as a model for T cell help to autoreactive B cells in systemic autoimmunity.