Terry Potter PhD
Professor of Immunology and Assistant Vice Chancellor for Academic Effectivness
T lymphocytes recognize antigenic peptides expressed on the cell surface in association with molecules encoded by the major histocompatibility complex. Recognition of a peptide-class I molecule by a T cell receptor (TCR) expressed on a CD8 T lymphocytes leads to cytokine production and to cytolysis of the presenting cell. Each individual T cell expresses a different TCR. During thymic development, thymocytes are subject to selection based on the binding specificity of their TCR. T cells with a TCR that is of too high or too low an affinity for self MHC molecules are deleted in the thymus. It is estimated that 90-95% of cells that enter the thymus never leave and die in situ. Our lab investigates 2 aspects of T cell development: (1) the contribution of the CD8 molecule to activation of T lymphocytes; (2) the mechanism by which cells that express a TCR that is of too low an affinity for self MHC molecules, die in the thymus.
- Potter T.A., Freiberg B., Grebe K. and Kupfer A. Supramolecular Activation Clusters are Formed on CD8+ T cells Following Coengagement of the TCR and CD8. PNAS 98: 12624-12629, 2001.
- Grebe KM and Potter TA. Enumeration, Phenotyping, and Identification of Activation Events in Conjugates Between T cells and Antigen-Presenting Cells by Flow Cytometry. Science STKE. 149 :PL14. 2002
- Grebe KM, Clarke, R. and Potter, TA. Ligation of CD8 leads to Apoptosis of Thymocytes that have not Undergone Positive Selection. PNAS 101:10410-10415, 2004.
View of Recent Publications in PubMed