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Kathryn Haskins, PhD

Professor of Immunology


 

 

 

 

Phone: 303-270-2093
Fax: 303-270-2325
Education & Training: University of Kansas (Lawrence, KS)-PhD, Biochemistry, 1981; Postdocotoral Fellowship in Immunology at National Jewish Health, 1981-1986
Email: katie.haskins@UCDenver.edu
Dr. Haskins' National Jewish Health webpage

T cell immunology, autoimmunity, type 1 diabetes. Our research is focused on the mechanisms and regulation of pathogenesis in the NOD mouse model of type 1 diabetes (T1D). We use cloned T cell lines and TCR transgenic mice to study the disease process. Our goals are to acquire better understanding of how CD4 T cells contribute to pathogenesis in T1D,   investigate the beta cell autoantigens that activate autoreactive T cells, and develop new strategies for inducton of tolerance and prevention of disease.

 
  • Haskins, K. 2005. Pathogenic T cell clones in autoimmune diabetes: more lessons from the NOD mouse. Advances in Immunol. 87: 123-62.
  • Cantor, J. and Haskins, K.  (2005) Effector Function of Diabetogenic CD4 Th1 T cell clones: A Central Role for TNFa.  J. Immunol. 175: 7738-45.
  • Cantor, J. and Haskins, K.  (2007) Recruitment and activation of macrophages by pathogenic CD4 T cells in T1D: Involvement of CCR8 and CCL1. J. Immunol. 179: 5760-67.
  • Tonkin, D.R., He, J., Barbour, G. and Haskins, K.  2008.  Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J. Immunol. 181: 4516-22
  • Tonkin, D.R. and Haskins, K.  2009.  Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-β-dependent manner.  Eur. J. Immunol. 39: 1313-22.
  • Stadinski, B.D.*, Delong, T.*, Reisdorph, N., Reisdorph, R., Powell, R.L., Armstrong, M., Piganelli, J.D., Barbour, G., Bradley, B., Crawford, F., Marrack, P., Mahata, S.K., Kappler, J.W. and Haskins, K.  2010. Chromogranin A is an autoantigen in type 1 diabetes.  Nature Immunology 11: 225-31.   *Denotes equal contributions.

 

View of Recent Publications in PubMed