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Aga Kendrick

Ph.D. Candidate, Department of Biochemistry and Molecular Genetics

Glubczyce, Poland
University of Wroclaw, Poland
Computational Chemistry, B.S.
University of Colorado Denver
Chemistry, M.S.
My research focuses on studying several of the primary mechanisms that underlay cancer progression with a particular emphasis on pancreatic cancer. I utilize combinations of biophysical, biochemical and cell-based techniques to assess the interactions and activities of two of the major proteins implicated in tumorigenesis and metastasis, which are Cyclophilin A (CypA) and the glycoprotein EMMPRIN (Extracellular Matrix Metalloproteinase). In recent years extracellular form of both CypA and EMMPRIN have emerged as key players in the regulation of disease progression, however, their specific interactions, the particular proteins regulated by CypA and EMMPRIN, and the role of EMMPRIN glycosylation have not been fully studied. Both CypA and EMMPRIN have been lately proposed to be markers of pancreatic cancer and thus, the characterization of the specific mechanism of their activity will provide insights into pancreatic cancer disease progression and the identification of novel therapeutic targets.