15-0743: Prospective Study of Magnetic Resonance Imaging (MRI) and
Multiparameter Gene Expression Assay in Ductal Carcinoma In Situ (DCIS)
PI: Wei Shin Wang, MD
The purpose of this study is to evaluate advanced imaging to
more accurately identify the anatomic extent of the disease with molecular
characteristics of Ductal
carcinoma in situ (DCIS)
and to more accurately characterize the biology of the disease rather than just
the symptoms and pathology of the disease. Ductal carcinoma in
situ (DCIS) is a non-invasive cancer where abnormal cells have been found
in the lining of the breast milk duct.
The atypical cells have not spread outside of the ducts into the surrounding
breast tissue. This integrated anatomical and biological
characterization from the Magnetic Imaging Resonance (MRI) of DCIS lesions is
expected to better stratify the need for therapeutic interventions, while
maintaining excellent clinical outcomes, facilitating more informed shared
decision making, and preserving quality of life.
For more information about
this trial, please visit http://ecog-acrin.org/clinical-trials/e4112-educational-materials or www.clinicaltrials.gov NCT number: NCT02352883
14-2053: Clinical Validation of a Predictive Model for the Presence of Cervical Lymph Node Metastasis in Papillary Thyroid Cancer
Principal Investigator: Nayana Patel, M.D.
The purpose of this study is to compare the accuracy of two methods of lymph node evaluation using ultrasound in patients who have papillary thyroid cancer (PTC): research method vs. standard method. The standard method is what is usually performed as standard of care where the radiologist evaluates the ultrasound images of the lymph nodes overall and decides whether each node seen should or should not be biopsied. In the research method, a radiologist evaluates the ultrasound images of the lymph nodes and uses a small, specific checklist of ultrasound appearance to determine whether each node should or should not be biopsied. Information from both of these evaluation methods is recorded to determine which method more accurately identifies the cancer in the lymph node.
For more information about this trial, please visit http://www.mdlinx.com/oncology/clinical-trials/clinical-trial-detail.cfm?nct_id=NCT02442661 or www.clinicaltrials.gov NCT number: NCT02442661
10-1335: ACRIN 6690: A
Prospective, Multicenter Comparison of Multiphase Contrast-Enhanced CT and
Multiphase Contrast- Enhanced MRI for Diagnosis of Hepatocellular Carcinoma and
Liver Transplant Allocation
PI: Samuel Chang, MD, MS
The purpose of this study is to determine and compare the accuracy of
computed tomography (CT) scans and magnetic resonance imaging (MRI) in diagnosing liver
cancer. The most effective way to treat patients with liver cancer and
other liver disease may be liver transplantation. With improved imaging
methods, the study doctors believe they can improve current methods of listing
patients with advanced liver disease on the waitlist for liver transplant. To
discover which imaging method gives a clearer picture of liver disease, the
images from both the CT and MRI scans will be compared to the actual liver
after it is removed during transplant surgery and examined.
For more information about
this trial, please visit www.clinicaltrials.gov NCT number: NCT01082224