Department of Radiology

Ongoing Research Support

1R21AG026635-01A2    Cordes (PI)  09/1/2007-6/30/2010
NIH/NIA  
Functional MRI and Alzheimer’s disease
The overall goal of this project is to obtain an accurate statistical map of memory activation in the hippocampus (and associated structures in the limbic system) in older subjects, age 60 to 75.  The successful completion of our objectives would lead to an fMRI-based diagnostic test for memory impairment to help characterize abnormal memory function in people at risk for Alzheimer’s disease.
Role:  PI

1 P50 MH079485-01A1    Banich (PI)  04/22/08–1/31/13 
NIH/NIMH              
Interdisciplinary Behavioral Science Center: Determinants of Executive Function and Dysfunction
This center grant uses behavioral, neuroimaging, and computational methods to examine executive function.
Role:  Investigator

Completed Research Support

5P50HD033812-10 Berninger (Program PI) 03/01/96 - 11/30/2010
 Richards (PI, Project IV – Brain Imaging) 
NIH/NICHD
Learning Disabilities: Links to Schools and Biology
The major goal of this project is to use MR spectroscopy and functional MRI to study brain activation in children with learning disabilities.
Role:  Co-Investigator, Brain Imaging

5P30HD002274-38 Guralnick (Program PI) 08/01/89 - 6/30/2009
  
NIH/NICHD
Research in Mental Retardation and Child Development
This grant supports five scientific core facilities and one administrative core to enhance the effectiveness of scientists carrying out their research as part of our MRDDRC. The scientific core support facilities are as follows: (1) Genetics, (2) Neuroscience, (3) Behavioral Science, (4) Infant Primate Research Laboratory, and (5) Instrument Development Laboratory.
Role: Investigator, Brain Imaging in Neuroscience Core

Cordes (PI) 10/1/2002 - 9/30/2003
Royalty Research Fund, University of Washington
Using independent component analysis to analyze functional MR data.
The major goals of this project were to develop a new dimensionality-reduction method for analyzing
functional MR data using Independent Component Analysis.
Role:  PI

Selected Peer-reviewed Publications (selected from 37 peer-reviewed publications and 74 ISMRM proceedings) * indicates mentored postdoctoral fellows (mentorship D. Cordes).

Most relevant to the current application

1.   R. Nandy* and D. Cordes. A Novel Nonparametric Approach to Canonical Correlation Analysis with Applications to Low CNR Functional MRI Data. Magn. Reson. Med. 50:354-365 (2003).

2.   R. Nandy* and D. Cordes. Improving the Spatial Specificity of Canonical Correlation Analysis in fMRI. Magn. Reson. Med. 52:947-952 (2004).

3.   R. Nandy* and D. Cordes. A Semi-Parametric Approach to Estimate the Family-Wise Error Rate in fMRI using Resting-State Data. Neuroimage Feb 15;34(4):1562-76 (2007).

4.   D. Cordes and R. Nandy*. Independent Component Analysis in the Presence of Noise in fMRI. Magn Reson Imag, 25(9):1237-48 (2007).

5.   L. Stanberry*, A. Murua, D. Cordes. Functional Connectivity Mapping using the Ferromagnetic Potts Spin Model. Human Brain Mapping 29 (4): 422-440 (2008).

Patents:         

D. Cordes. P98110US. Functional Magnetic Resonance Imaging using Optimized Z-Gradients, 2000.

Additional recent publications of importance to the field

1.   D. Cordes, V. Haughton, K. Arfanakis*, G. Wendt, P. Turski, C. Moritz, M. Quigley, M. Meyerand. Mapping Functional Related Regions with Functional Connectivity MRI.  Am J Neuroradiol 21:1636-1644 (2000).

2.   D. Cordes, P. A. Turski, J. A. Sorenson. Compensation of Susceptibility-Induced Signal Loss in Echoplanar Imaging for Functional Applications. Magn Res Imaging 18:1055-1068 (2000).

3.   T. Stein, C. Moritz, M. Quigley, D. Cordes, V. Haughton, E. Meyerand. Functional Connectivity in the Thalamus and Hippocampus studied with fMRI. Am J Neuroradiol 21:1397-1401 (2000).

4.   D. Cordes, K. Arfanakis*, J. Carew, V. Haughton. Frequencies Contributing to Functional Connectivity in the Cerebral Cortex in “Resting-State” Data. Am J Neuroradiol. AJNR 22:1326-1333 (2001).

5.   D. Cordes, V. Haughton, J. Carew, K. Arfanakis*, K. Maravilla. Hierarchical Clustering to Measure Connectivity in fMRI Resting-State Data. Magn Res Imaging 20:305-317 (2002).

6.   L. Stanberry*, R. Nandy*, D. Cordes. Cluster Analysis of fMRI Data using Dendrogram Sharpening. Hum Brain Mapp 20:201-219 (2003).

7.   R. Nandy* and D. Cordes. Novel ROC-type Method for Testing the Efficiency of Multivariate Statistical Methods in fMRI.  Magn. Reson. Med. 49:1152-1162 (2003).

8.   R. Nandy* and D. Cordes. New Approaches to ROC Methods in Functional Magnetic Resonance Imaging with Real Data using Repeated Trials. Magn. Reson. Med. 52:1424-1431 (2004).

9.   L. Stanberry*, T. Richards, V. Berninger, R. Nandy*, E. Aylward, K. Maravilla, D. Cordes. Low-frequency signal changes reflect differences in functional connectivity between good readers and dyslexics during continuous phoneme mapping. Magn. Reson. Imag. 24:217-229 (2006).

10. D. Cordes, R. Nandy*. Estimation of the Intrinsic Dimensionality of fMRI Data. Neuroimage 29:145-154 (2006).

• Member, Sigma Pi Sigma Physics Honor Society
• Member, The American Physical Society
• Member, International Society of Magnetic Resonance in Medicine
• Member, Organization of Human Brain Mapping
• Member, International Society for Neural Networks
• NIH reviewer for study section CND (01) Clinical Neurological Disease
• Associate Editor of the journal Computerized Medical Imaging And Graphics
• Associate Editor of the journal Medical Physics