The research in our laboratory focuses on the neuropharmacology of drugs of abuse, particularly alcohol (ethanol), including mechanisms of neuroadaptation (tolerance and dependence), neuronal toxicity, and craving or preference for alcohol. We use a global, systems-based approach which uses genomic (RNA-Seq and microarray analysis of gene expression) and genetic techniques, as well as bioinformatic analyses, to identify candidate genes that may contribute to complex alcohol-related and other CNS-relevant traits, including alcohol tolerance and preference. We use RNAi-based technologies for in vivo modulation of the expression of the candidate genes in particular brain areas and we evaluate the behavioral consequences of this modulation. Overall, biochemical, molecular biological, genetic/genomic and behavioral techniques characterize our research.