Our main research goal is to
understand how gene networks control cell behavior in homeostasis and human
disease. Our two main focus areas are cancer biology and Down syndrome.
We are a multidimensional team of
biologists employing a wide range of approaches from biochemistry to functional
A long-term goal of our research is
to decrease the unacceptable amount of death and sorrow caused by cancer.
Nonetheless, our discoveries often lead us into other areas of biomedical
research or into more fundamental biological problems without immediate
We understand cancer as a genetic
disease caused by mutations in oncogenes and tumor suppressor genes. We believe
that understanding the mechanism of action of these cancer genes will reveal
strategies to reduce the burden of cancer in our society.
We abhor the use of poisonous
chemotherapy and radiation to treat patients. We consider Personalized
Precision Medicine employing Molecular Diagnostics and Biologically Targeted
Therapies to be the only viable path toward a cure.
We employ biochemistry, molecular
biology, cell biology, genetics, genomics, bioinformatics, animal models and
art to investigate cancer genes. Our studies aim to produce discoveries that
could be employed in the clinic for better prevention, diagnosis and treatment
Another major area of research in
our lab is trisomy 21 and Down syndrome. Supported by the Linda Crnic Institute
for Down syndrome, our research aims to elucidate the impacts of trisomy 21 at
the molecular, cellular and organismal levels. More specifically, we aim to
define the mechanisms by which trisomy 21 causes a different disease spectrum
in the population with Down syndrome, protecting from some conditions (e.g. solid
tumors, hypertension), while predisposing to others (e.g. Alzheimer’s disease,
autoimmune disorders, autism).
To learn more about our science,
please read visit our lab website espinosalab.org