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Department of Pharmacology

Department of Pharmacology
 

Timothy Benke, MD PhD

Associate Professor


Contact Information:

University of Colorado Denver
Department of Pharmacology
Mail Stop 8303, RC1-North
12800 East 19th Ave
Aurora CO 80045

Phone: (303) 724-3568
Fax: (303) 724-3663
E-mail: tim.benke@ucdenver.edu
curriculum vitae

Affiliated Programs

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My laboratory studies the function of synapses, the primary means of communication between neurons in the brain. Discoveries include mechanisms for synaptic changes that are likely associated with learning and memory. Research is directed at discovering how synapses change with development and following seizures.  Our results are specifically directed to help prevent and treat the effects of early-life seizures (ELS), which can include autism, learning impairment and epilepsy.
We focus primarily on the hippocampus in rodents using direct observations of synaptic function with field recordings and whole-cell patch clamp measurements of synaptic events in living brain slices.  Western-blot techniques and immunohistochemistry are used to probe protein expression and localization.  Pharmacological manipulations are added to determine potential therapies.  We use in vivo behavioral techniques to further confirm and advance our translational findings back to the bedside.

Clinical projects outside the lab run intellectually in parallel.  We are interested in determining the molecular basis and natural history of autism, epilepsy and intellectual disability.  We focus on Rett syndrome (MeCP2 related disorders), CDKL5 syndrome, infantile spasms and Down syndrome.  All of these disorders can be associated with autism, epilepsy and intellectual disability.

Current Lab Members 

 Results From Personnel : Selected site and subsites
First NameLast NameMiddle InitialDegreePosition
PaulBernardB.PhDPostdoctoral Fellow
AnnaCastano BSProfessional Research Assistant
HeatherO'LearyE.PhDPostdoctoral Fellow

  

Previous Trainees 

 Results From Personnel : Selected site and subsites
First NameLast NameMiddle InitialDegreePosition
BrandonCornejoJ.PhDPostdoctoral Fellow
AllisonGehrke BSGraduate Student
ElizabethStubblefieldA.PhDGraduate Student