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Jacobsen Lab

There are three main areas of study in the Jacobsen lab that focus on breast cancer:
1) Examining the role of a secreted mucin, mucin-2, on the biology of breast cancer 
2) Examining the role of the tyrosine kinase receptor, c-Kit, on the growth and metastasis of Invasive lobular breast carcinoma (ILC) 
3) Examining the role of progesterone in mediating the biology of ILC including growth and metastasis. 
We employ a variety of models including a panel of novel breast cancer cell lines that we have generated from patient derived xenografts. These breast cancer models are used by investigators nationally and internationally.  

Complete list of publications:

Selected Publications:
1. Estrogen induces c-Kit and an aggressive phenotype in a model of invasive lobular breast cancer. Harrell JC, Shroka TM, Jacobsen BM.  Oncogenesis. 2017; 6(11):2. PMID: 29176653 
2. Cooperative Dynamics of AR and ER Activity in Breast Cancer.  D'Amato NC, Gordon MA, Babbs B, Spoelstra NS, Carson Butterfield KT, Torkko KC, Phan VT, Barton VN, Rogers TJ, Sartorius CA, Elias A, Gertz J, Jacobsen BM, Richer JK. Molecular cancer research: MCR. 2016; 14(11):1054-1067. NIHMSID: NIHMS813401  PMID: 27565181 PMCID: PMC5107172 
3. Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features. Jambal P, Badtke MM, Harrell JC, Borges VF, Post MD, Sollender GE, Spillman MA, Horwitz KB, Jacobsen BM. Breast cancer research and treatment. 2013; 137(2):431-48. NIHMSID: NIHMS430107   PMID: 23247610 PMCID: PMC3543987 
4. Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel. Schlaepfer IR, Hitz CA, Gijón MA, Bergman BC, Eckel RH, Jacobsen BM. Molecular and cellular endocrinology. 2012; 363(1-2):111-21. NIHMSID: NIHMS739467   PMID: 22922095 PMCID: PMC4671297 
5. Progesterone receptors, their isoforms and progesterone regulated transcription. Jacobsen BM, Horwitz KB.   Molecular and cellular endocrinology. 2012; 357(1-2):18-29. NIHMSID: NIHMS326325  PMID: 21952082 PMCID: PMC3272316 
6. Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpoint.  Badtke MM, Jambal P, Dye WW, Spillman MA, Post MD, Horwitz KB,   Jacobsen BM. Breast cancer research and treatment. 2012; 131(1):75-87. NIHMSID: NIHMS291296 PMID: 21340479 PMCID: PMC3875321

Lab Address: 
University of Colorado | Anschutz Medical Campus
Research Complex 1 North, Room 5404D
12800 East 19th Ave
Aurora, CO 80045-0611

Phone: 303-724-3939
Mail Stop: 8104