FISH for chromosome abnormalities common in pregnancy loss may be indicated when a tissue fails to grow in culture for standard cytogenetic studies or on archived tissue where standard cytogenetics cannot be performed.
FISH studies involve scoring of hybridization signals using chromosome-specific DNA probes on interphase nuclei.
- When FISH for chromosome abnormalities common in pregnancy loss is performed subsequent to culture failure for standard chromosome analysis, no additional specimen would be required.
- See specimen requirements for appropriate chromosome analysis.
- These studies can also be performed on formalin fixed, paraffin embedded tissue. Provide 4-5 micron thick paraffin sections on 8-10 Plus slides.
Sample must be accompanied by a completed Test Request Form, including pertinent clinical and family history.