Skip to main content
Sign In

You have reached the Web site for the Department of Pathology at the University of Colorado Denver.

Colorado Genetics Labs
Colorado Genetics Laboratory
 

FISH for Chromosome Abnormalities Common in Pregnancy Loss


Indications

FISH for chromosome abnormalities common in pregnancy loss may be indicated when a tissue fails to grow in culture for standard cytogenetic studies or on archived tissue where standard cytogenetics cannot be performed.


 

Methodology

FISH studies involve scoring of hybridization signals using chromosome-specific DNA probes on interphase nuclei.


 

Specimen Requirements

    • When FISH for chromosome abnormalities common in pregnancy loss is performed subsequent to culture failure for standard chromosome analysis, no additional specimen would be required.
    • See specimen requirements for appropriate chromosome analysis.
    • These studies can also be performed on formalin fixed, paraffin embedded tissue. Provide 4-5 micron thick paraffin sections on 8-10 Plus slides.

 

Sample must be accompanied by a completed Test Request Form​​, including pertinent clinical and family history.​​