University of Colorado Denver
School of Medicine, Division of Medical Oncology
12801 E. 17th Ave., MS 8117, Aurora, CO 80045
Phone: (303) 724-3873
Fax: (303) 724-3889
The Schedin Lab is focused on developing breast cancer chemopreventive strategies that are targeted to specific windows of breast development. Our approach is to understand the role of tissue remodeling in mediating epithelial cell function during key windows of normal mammary gland differentiation, such as adolescent mammary gland development and the pregnancy, lactation, and involution cycle. Major areas of investigation include mammary epithelial cell / stromal interactions, pregnancy-associated breast cancer, tumor dormancy, and chemoprevention using rodent, 3-dimensional culture models and human tissue. Current Research Projects Include: 1) Determining the role of physiologic tissue remodeling in promoting metastasis in pregnancy-associated breast cancer. 2) Developing target therapies for prevention and treatment of pregnancy-associated breast cancer, and 3) Identify stromal mediators of tumor cell dormancy and metastasis by characterizing the ECM proteomes of the ‘breast-cancer protected’ and ‘at-risk’ mammary gland.
1. Rhonda H. et al., Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes. Breast Cancer Res, Jan 27;11(1):R5. Epub 2009 Jan 27
2. Billups C. et al., Identifying Significant Temporal Variation in Time Course Microarray Data Without Replicates. BMC Bioinformatics, 2009 Mar 26; 10:96
3. Hansen K, et al., An In-Solution Ultrasonic Assisted Digestion Method for Improved Extracellular Matrix Proteome Coverage. Mol Cell Proteomics. 2009 Jul;8(7):1648-57.
4. O’Brien J, Schedin P. Macrophages in Breast Cancer: Do Involution Macrophages Account for the Poor Prognosis of Pregnancy-Associated Breast Cancer? J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):145-57.
5. Lyons T et al., Pregnancy and Breast Cancer: When They Collide. J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):87-98.
6. O’Brien J et al, Alternatively activated macrophages and collagen remodeling characterize the post-partum involuting mammary gland across species. Am J Pathol, in press, Jan, 2010.
7. Schedin, P., Pregnancy-associated breast cancer and metastasis. Nature Reviews Cancer, 6:281-291, 2006.
1. Schedin, P., PI, ‘The inflammatory milieu permits metastasis in pregnancy associated breast cancer’. DOD Synergistic Idea.
2. Schedin, P., PI, ‘Targeting the pro-inflammatory milieu of the involuting gland to suppress pregnancy associated breast cancer metastasis’. Komen Foundation.
3. Schedin, P., PI, ‘Defining the dormant tumor microenvironment for breast cancer prevention and treatment’. DOD Idea Award.
4. Schedin, Co-PI, Steve Anderson, Co-PI, ‘Modulation of Obesity Induced breast cancer risk by metformin’. Komen Foundation.