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Bolin Liu, MD

Assistant Professor


Education:

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MD, Beijing Medical University, Beijing, China (1987)

MS, Institute of Hematology, Peking Union Medical College (PUMC) and Chinese Academy of Medical Science (CAMS), Tianjin, China (1994)

 

Postdoctoral Education:

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Postdoctoral Fellow Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center (UTMDACC), Houston, TX (1998-2001)

Visiting Scientist Department of Surgical Oncology, UTMDACC, Houston, TX (1994-1998)

 

Research Activities:

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ErbB receptor tyrosine kinase-mediated signaling in breast cancer.

Biological functions of death effector domains (DEDs) in caspase-8 activation during apoptosis.

Epigenetic modulation in multiple myeloma

View Research Page

 

Selected Publications:

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Liu B, Sun D, Xia W, Hung M-C, Yu D: Cross-reactivity of C219 anti-p170mdr-1 antibody with p185c-erbB2 in breast cancer cells: cautions on evaluating p170mdr-1. Journal of the National Cancer Institute 89: 1524-1529, 1997 (Editorials by Helen S. L. Chan, Victor Ling).

Yu D, Jing T, Liu B, Yao J, Tan M, McDonnell TJ, Hung M-C: Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21cip1 that inhibits p34cdc2 kinase. Molecular Cell 2(5): 581-591, 1998.

Liu B, Fang M, Schmidt M, Lu Y, Mendelsohn J, Fan Z: Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. British Journal of Cancer 82(12): 1991-1999, 2000.

Liu B, Fan Z: The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway. Oncogene 20: 3726-3734, 2001.

Liu B, Fang M, Lu Y, Mendelsohn J, Fan Z: Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. Oncogene 20: 1913-1922, 2001.

Liu B, Peng D, Lu Y, Jin W, and Fan Z: A Novel Single Amino Acid Deletion Caspase-8 Mutant in Cancer Cells That Lost Proapoptotic Activity. Journal of Biological Chemistry. 277: 30159-30164, 2002.

Liu B, Edgerton SM, Yang X, Ordonez-Ercan D, Kim A, Mason TL, Alvarez KM, McKimmey CC, Liu N, Thor AD: Dietary Phytoestrogen Abrogates Tamoxifen Associated Mammary Tumor Prevention. Cancer Research. 65(3): 879-886, 2005.

Ding W-Q, Liu B, Vaught JL, Yamauchi H, Lind SE: Anti-Cancer Activity of the Antibiotic Clioquinol. Cancer Research. 65(8): 3389-3395, 2005.

Kim A, Liu B, Ordonez-Ercan D, Alvarez KM, Jones L, McKimmey C, Edgerton SM, Yang X, Thor AD: Functional interactions between mouse erbB-3 and wild type rat c-neu in transgenic mouse mammary tumor cells. Breast Cancer Research 7:R708-R718, 2005 * Equal contribution.

Ding W-Q, Liu B, Vaught JL, Richard D, Palmiter RD, Lind SE: Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells. Molecular Cancer Therapeutics. 5(7): 1864-72, 2006

Liu B, Ordonez-Ercan D, Fan Z, Edgerton SM, Yang X, Thor AD: Down-regulation of ErbB3 Abrogates ErbB2-mediated Tamoxifen Resistance in Breast Cancer Cells. International Journal of Cancer. 120: 1874-1882, 2007 * Corresponding Author

Alimova IN, Liu B, Fan Z, Edgerton SM, Dillon T, Lind SE, Thor AD: Metformin Inhibits Breast Cancer Cell Growth, Colony Formation and Induces Cell Cycle Arrest In Vitro. Cell Cycle 8: 909-915, 2009.

Liu B, Fan Z, Alimova IN, Edgerton SM, Thor AD: Metformin Induces Apoptosis in Triple Negative Breast Cancer Cells. Cell Cycle 8: 2031-2040, 2009.

Liu B, Ordonez-Ercan D, Fan Z, Huang XP, Edgerton SM, Alvarez KM, Yang X, Thor AD: Estrogenic Promotion of ErbB2 Tyrosine Kinase Activity in Mammary Tumorigenesis Requires Activation of ErbB3 Signaling. Molecular Cancer Research 7(11):1882-1892, 2009.

Huang XP, Gao L, Wang S, Lee C-K, Ordentlich P, Liu B: HDAC inhibitor SNDX-275 induces apoptosis in erbB2-overexpressing breast cancer cells via downregulation of erbB3 expression. Cancer Research 69(21):8403-8411, 2009.

 

Office Location:

 Research Center 1 South

 Room 5118

 

Contacts:

 Email:

 Office Phone:

 Lab:

 Fax:

Bolin.Liu@ucdenver.edu

(303) 724-3749

(303) 724-3750

(303) 724-3712

 

Mailing Address:

 University of Colorado Anschutz Medical Campus

 12801 East 17th Avenue

 Mail Stop 8104

 Aurora, CO 80045​​​