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Christina C. Leslie, PhD

Professor


Education:

 – BS, Microbiology, University of Massachusetts

 – MS, Microbiology, University of Georgia

 – PhD, Microbiology, University of Georgia

 

Research Activities:

 – Biochemical properties and regulation of Mammalian Phospholipases A2

 – Regulation of Phospholipase A2 and lipid mediator production in macrophages during infection

 

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Gijon MA, Spencer DM, Siddiqi AR, Bonventre JV, Leslie CC: Cytosolic phosholipase A2 is required for macrophage arachidonic acid release by agonists that do and do not mobilize calcium. J. Biol. Chem., 275:20146-20156 (2000).

Evans JH, Spencer DM, Zweifach A, Leslie CC: Calcium requirements for cytosolic phospholipase A2 translocation to internal membranes. J. Biol. Chem., 276:30150-30160 (2001).

Panini S, Yang L, Rusinol A, Bonventre JV, Sinensky M, Leslie CC: Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol. J. Lipid Research, 42:1678-1686 (2001).

Stewart A, Leslie CC: Properties and regulation of human cytosolic phospholipase A2?. J. Biol. Chem. 277:29525-29536 (2002).

Evans JH, Fergus DJ, and Leslie CC: Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA2 phosphorylation and translocation. BMC Biochem. 3:30 (2002).

Ghosh M, Stewart A, Tucker DE, Bonventre JV, Murphy RC, Leslie CC: Role of cytosolic phospholipase A2 in prostaglandin E2 production by lung fibroblasts. Amer. J. Respir. Cell Mol. Biol. 30:91-100 (2004).

Evans JH, Gerber SH, Murray D, Leslie CC: The calcium binding loops of the cytoplasmic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cells. Mol. Biol. Cell 15:371-383 (2004).

Evans JH, Leslie CC: The cytosolic phospholipase A2 catalytic domain modulates association and residence time at Golgi membranes. J. Biol. Chem. 279:6005-6016 (2004).

Leslie CC, Gelb MH: Assaying phospholipase A2 activity. Methods Mol. Biol. 284:229-242 (2004).

Leslie CC: Regulation of arachidonic acid availability for eicosanoid production. Biochem. Cell Biol. 82: 1-17 (2004).

Leslie CC: Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2. Prostaglandins Leukotrienes Essen. Fatty Acids 70:373-376 (2004).

Girotti M, Evans JH, Burke D, Leslie CC: Cytosolic phospholipase A2 translocates to forming phagosomes during phagocytosis of zymosan in macrophages. J. Biol. Chem. 279:19113-19121 (2004).

 

Office Location:

 National Jewish Medical and Research Center

 Department of Pediatrics

 Room K906

 

Contacts:

 Email:

 Office Phone:

 Fax:

lesliec@njc.org

(303) 398-1214

(303) 270-2155

 

Mailing Address:

 National Jewish Medical and Research Center

 1400 Jackson Street

 Denver, CO 80206​​​​​​​​