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Liming Bao, MD, PhD, FACMG

Professor, Director of Colorado Genetics Laboratory; Clinical Cytogenetics/Molecular Genetics/Leukemia Genomics Research


​Education:
  • MD, Fudan University Shanghai Medical College, China (1985)
  • MS, Fudan University Shanghai Medical College, China (1988)
  • PhD, University of South Alabama College of Medicine (1996)

Postdoctoral Education:
  • Research Fellow, University of Colorado School of Medicine (1996-1997)
  • Fellowship, Clinical Molecular Genetics, University of Colorado School of Medicine (1997-1999)
  • Fellowship, Clinical Cytogenetics, University of Colorado School of Medicine (1999-2000)

Board Certifications:
  • C​linical molecular genetics 
  • Clinical cytogenetics 

Subspecialties:
  • Clinical cytogenetics
  • Clinical molecular genetics

Research Activities:
  • Leukemia genom​ic profiling and clinical relevance

Select Recent Publications:
Lv L, Wu C, Sun H, Zhu S, Yang Y, Chen X, Fu H, Bao L. Combined 677CC/1298AC genotypes of methylenetetrahydrofolate reductase (MTHFR) reduce susceptibility to precursor B lymphoblastic leukemia in a Chinese population Eur J Haematol. 2010;84(6):506-12.
Xu YJ, Wang J, Xu R, Zhao PJ, Wang XK, Sun HJ, Bao L, Shen J, Fu QH, Li F, and Sun Kun. Detecting 22q11.2 deletion in Chinese children with conotruncal heart defects and single nucleotide polymorphisms in the haploid TBX1 locus. BMC Med Genet. 2011;12:169. 
Miller EM, Hopkin R, Bao L, Ware SM. Implications for genotype-phenotype prediction in Townes-Brocks syndrome: Case report of a novel SALL1 deletion and review of the literature. Am J Med Genet A. 2012;158A:533-40.
Chen X, Yang Y, Huang Y, Tan J, Chen Y, Yang J, Fou H, Zou L,Yu  J, Bao  L. WT1 Mutations and Single Nucleotide Polymorphism rs16754 Analysis of Patients with Pediatric Acute Myeloid Leukemia in a Chinese Population. Leuk Lymphoma. 2012;53(11):2195-204. 
Sund K, Zimmerman S, Thomas C, Mitchell A, Prada C, Grote L, Bao L, Martin L, Smolarek T. Regions of homozygosity identified by SNP microarray analysis aid in the diagnosis of autosomal recessive disease and incidentally detect parental blood relationships. Genet Med. 2013;15(1):70-8
Yang J, Yang Y, Huang Y, Zeng F, Hu Y, Li H, Lv Z, Cheng Q, Bao L. A Study of two Chinese patients with tetrasomy and pentasomy 15q11q13 including Prader-Willi/Angelman syndrome critical region present with development delays and mental impairment. BMC Med Genet. 2013;14:9-17.
Miao JK, Chen QX, Bao L, Huang Y, Yi Y, Wang SY, Zou L, Li TY. Determination of optimal cutoff value to accurately identify glucose-6 -phosphate dehydrogenase-deficient heterozygous female neonates. Clinica Chimica Acta. 2013;424:131-5.
Yuan L, Yang Y, Gou G, Sun H, Lu L, Bao L. HLA class II alleles may influence susceptibility to adult polymyositis and dermatomyositis in a Han Chinese population. BMC Dermatology 2014;14:9-16.
Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B. The E3 Deubiquitinase USP17 Is a Positive Regulator of Retinoic Acid-related Orphan Nuclear Receptor γt (RORγt) in Th17 Cells. J Biol Chem. 2014;12;289(37):25546-55.
Sonya Barnes; You-Hai Xu; Wujuan Zhang; Benjamin Liou; Kenneth DR Setchell; Liming Bao; Gregory A Grabowski; Ying Sun. Ubiquitous Transgene Expression of the Glucosylceramide-Synthesizing Enzyme Accelerates the Phenotype in a Gaucher Disease Mouse Model. PLOS ONE. 2014;9(12):e116023.
Yuan L, Lu L, Yang Y, Sun H, Chen X, Huang Y, Wang X, Zou L, Bao L. Genetic mutational profiling analysis of T-cell acute lymphoblastic leukemia reveal mutant FBXW7 as a prognostic indicator for inferior survival. Annal Hematol. 2015;94:1817-28.
Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L, Li b. TRAF5-Mediated K63-linked Polyubiquitination Play Essential Role  in Positive Regulation of RORγt on Promoting IL-17A Expression. J Biol Chem 2015;290(48):29086-94.
Huang Y, Yang M, Hu H,  Zhao X , Bao L, Huang D, Song L, Li Y. Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer. Oncotarget. 2016;7(27):41404-20.
Dou H, Chen X, Huang Y, Lu L, Yu J, Yin Y, Bao L. Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression vary across risk subgroups of childhood B-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2017;56:135-46.
He XY, Tan Zl, Mou Q, Liu FJ, Liu S, Yu CW, Zhu J, Lv LY, Zhang J, Wang S, Bao L, Peng B, Zhao H, and Zou L. microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase, and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma. Clin Cancer Res. 2017;1;23(11):2905-2918.
Tao J, He X, Shi Y, Zhu G, Liu S, Zhang Z, Tang S, Zhang R, Peng B, Liu Z, Tan J, Chen Q, Wang X, Bao L, Zou L, and Zhang P. Epidemiology of 45,616 suspect cases of Hand, Foot and Mouth Disease in Chongqing, China, 2011-¬2015. Scientific Report. 2017;7:45630.
Chen X, Dou H, Wang X, Huang Y, Lu L, Bin J, Su Y, Zou L, Yu J, and Bao L. KIT mutations correlate with adverse survival in children with core-binding factor acute myeloid leukemia. Leukemia Lymphoma. 2018;59(4):829-36.
Lu L, Bi J, and Bao L. Genetic profiling of cancer with circulating tumor DNA analysis. J Genet Genomics. 2018;45:79-85.
Wang X, Chen X, Yang Z, Dou H, Lu L, Bi J, Zou L, Yu J, and Bao L. Correlation of TET2 SNP rs2454206 with Improvement in Survivals in Children with Acute Myeloid Leukemia Featuring Intermediate-risk Cytogenetics. Genes Chromosomes Cancer. 2018