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Yashpal Agrawal, MD, PhD

Visiting Professor


Education:
MBBS MS University, Baroda, India (1977-1982)
PhD University of Kuopio, Kuopio, Finland (1984-1987)

Postdoctoral education:
House Staff, SSG Hospital, Baroda, India (1983-1984)
Research Assistant, Dept. of Anatomy, University of Kuopio, Finland (1984-1987)
Clinical Chemistry Residency, Kuopio University Hospital, Finland (1987-1993)
Fellowship, University of California, San Diego (1994-1995)
Anatomic Pathology Residency, Yale New Haven Hospital (1997-1999)
Clinical Pathology Residency, Massachusetts General Hospital, Boston (1999-2000)
Transfusion Medicine Fellowship, Massachusetts General Hospital, Boston (2000-2001)

Board Certifications:
Clinical Pathology, American Board of Pathology (2001)

Academic Positions: 
Senior Lecturer, University of Kuopio, Finland (1989-1991)
Clinical Assistant Professor, University of Iowa, IA (2001-2006)
Associate Professor, Weill Cornell Medical College (2006-2013)
Professor of Clinical Pathology and Laboratory Medicine, Weill Cornell College (2013-2014)
Visiting Professor of Pathology, University of Colorado, CO (2017-present)

Bibliography:
1. Vanha-Perttula T, Agrawal Y, Jauhianen A. Aminopeptidase A in reproductive organs of the male rat: evidence for high activity in the posterior lobe of prostate. Int J Androl 7: 419-430, 1984. PMID: 6549307 
2. Agrawal Y, Vanha-Perttula T.Variable distribution of aminopeptidase A in male reproductive organs of mammals. Int J Androl 8: 243-256, 1985. PMID: 3840455 
3. Agrawal Y, Vanha-Perttula T. Studies on the multiple forms of aminopeptidase A in bovine seminal vesicle secretion. Int J Biochem 18: 465-471, 1986. PMID: 3709933 
4. Agrawal Y, Vanha-Perttula T. Alanyl aminopeptidase of bovine seminal vesicle secretion. Int J Biochem 18: 725-729, 1986. PMID: 3743878 
5. Agrawal Y, Vanha-Perttula T. Dipeptidyl peptidases in bovine reproductive organs and secretions. Int J Androl 9: 435-452, 1986. PMID: 3570534 
6. Agrawal Y, Vanha-Perttula T. The effect of secretory particles in bovine seminal vesicle secretion on sperm motility and acrosome reaction. J Reprod Fert 79: 409-419, 1987. PMID: 3572875 
7. Agrawal Y. Distribution, secretion and properties of some exopeptidases in the male reproductive organs. Publ.Univ.Kuopio, Medicine 4:1-72, 1987. 
8. Agrawal Y, Vanha-Perttula T. Electron microscopic study of the secretion process in bovine reproductive organs. J Androl 9:307-316, 1988. PMID: 3235378 
9. Agrawal Y, Vanha-Perttula T. Glutathione, L-Glutamic acid and gamma-Glutamyl transpeptidase in the bull reproductive tissues. Int J Androl 11: 125-131, 1988. PMID: 2897339 
10. Agrawal YP, Vanha-Perttula T. -Glutamyl transpeptidase, glutathione and L-Glutamic acid in the rat epididymis during postnatal development. Biol Reprod 38:996-1000, 1988. PMID: 2900657 
11. Agrawal Y, Vanha-Perttula T: Biochemical and histochemical studies on Dipeptidyl Peptidases I-IV in the bovine reproductive organs. Biol Zent Biol 107:211-214, 1988. PMID: not available 
12. Agrawal YP, Vanha-Perttula T. -Glutamyl transpeptidase in murine epididymis: distribution and response to acivicin. J Reprod Fert 86:185-193, 1989. PMID: 2569039 
13. Agrawal YP, Vanha-Perttula, T. -Glutamyl transpeptidase in rat epididymis: Effects of castration, hemicastration and efferent duct ligation. Int J Androl 12:321-328, 1989. PMID: 2572565 
14. Vanha-Perttula T, Agrawal YP. The role of enzymes in post-testicular maturation of spermatozoa. Molecular Andrology 2:1-34, 1989. PMID: not available 
15. Letters to the Editor: Räsänen M, Saaranen M, Penttilä I, Agrawal YP. Flow cytometry for measurement of antibodies to spermatozoa in subfertile men. Lancet 336:887-888, 1990. PMID: 1976921 
16. Agrawal YP, Mahlamäki E: Terminaalinen deoksinukleotidyylitransferaasi (TdT) värjäyksenkäyttö hematologiassa. Kliin Lab 3:65-67, 1991 (Finnish). PMID: not available 
17. Agrawal YP, Mahlamäki E, Penttilä IM. Use of quality control standards in clinical flowcytometry. Annals of Medicine 23:127-133, 1991. PMID: 2069789 
18. Räsänen ML, Hovatta OL, Penttilä IM, Agrawal YP. Detection and quantitation of 
sperm bound antibodies by flow cytometry of human semen. J Androl 13:55-64, 1992. PMID: 1372598 
19. Agrawal YP, Hämälainen E, Mahlamäki EK, Aho H, Nousiainen T, Lahtinen R, Penttilä IM. Comparison of poly- and monoclonal antibodies for determination of B-cell clonal excess in a routine clinical laboratory. Eur J Haematol 48:49-55, 1992. PMID: 1730280 
20. Letters to the Editor: Agrawal, YP, Penttilä IM. Reticulocyte analysis by flow cytometry using a modified gating procedure. Eur J Haematolol 48: 58-60, 1992. PMID: 1730282 
21. Agrawal YP: Methodological aspects of the flow cytometric quantitation of cell surface antigens and antibodies. Kliin Lab 10:17-20, 1993. PMID: not available 
22. Räsänen M, Lähteenmäki A-M, Saarikoski S, Agrawal YP. Comparison of flowcytometric measurement of seminal antisperm antibodies with the Mixed Antiglobulin Reaction and the Serum Tray Agglutination Test. Fertil Steril 61:143-150, 1994. PMID: 8293829 
23. Agrawal RS, Agrawal YP, Mäntyjärvi R. Flow cytometric quantitation of c-myc and p53 proteins in bovine papilloma virus type 1 transformed primary mouse fibroblasts. Cytometry 17:237-245, 1994. PMID: 7851159 
24. Räsänen M, Saarikoski S, Penttilä I, Agrawal YP. A flow cytometric study on the effect of low dose cyclic prednisolone treatment on sperm-bound antibody levels. Hum Reprod 9:889-893, 1994. PMID: 7929738 
25. Agrawal YP, Ylikängas P, Parviainen MT, Penttilä IM. Flow cytometric method to measure urea resistant alkaline phosphatase from blood neutrophils for use in the antenatal screening of Down’s syndrome Prenat Diagn 14:1141-1149, 1994. PMID: 7899281 
26. Penttila I, Agrawal YP, Hirvonen K, Hongisto T, Julkunen A, Rantanen T. Modifioitu seerumin troponiini-T:n määritys mikrotiitterilevyllä akuutin sydäninfarktin diagnostiikassa. Kliin Lab2:35-39, 1994 (Finnish). PMID: not available 
27. Räsänen M, Agrawal YP, Saarikoski S. Seminal fluid antisperm antibodies 
measured by direct flowcytometry do not correlate with those measured by indirect flow cytometry, the indirect immunobead test and the indirect mixed antiglobulin reaction. Fertil Steril 65:170-5, 1996 PMID: 8557136 
28. Räsänen M, Lähteenmäki A, Agrawal YP, Saarikoski S, Hovatta O. A placebo controlled flow cytometric study on the effect of low dose prednisolone treatment on sperm-bound antibody levels. Int J Androl 19:150-154, 1996. PMID: 8876264 
29. Agrawal YP, Agrawal RS, Sinclair A, Young D, Maruyama M, Levine F, Ho AD. Cell cycle kinetics and VSV-G pseudotyped retrovirus mediated gene transfer in blood derived CD34+ cells. Exp Hematol 24:738-747, 1996. PMID: 8635530 
30. Sinclair AM, Agrawal YP, Elbar EL, Ho AD, Levine F. VSV-G pseudotyped retrovirus efficiently binds and fuses to CD34+ and CD34+CD38- hematopoietic progenitor cells. Gene Therapy, 4:918-27,1997. PMID: 9349428 
31. Agrawal RS, Karhu, K, Kirkinen P, Ylä-Herttuala S, Agrawal YP. Complement and anti-α-galactosyl natural antibody mediated inactivation of murine retrovirus occurs in adult serum but not in umbilical cord serum. Gene Therapy, 6:146-148, 1999. PMID: 10341887 
32. Agrawal YP. Platelet Flowcytometry: limitations and possibilities. Klinisk Kemi I Norden 4:92-96, 1999. PMID: not available 
33. Letters to the editor: Agrawal YP, Dzik S. The von Willebrand factor content of factor VIII concentrates. Transfusion 41:153-4, 2001. PMID: 11161262 
34. Agrawal YP, Freedman M, Szczepiorkowski ZM. The effects of long term transfusion of polymerized bovine hemoglobin in a Jehovah’s witness following chemotherapy for myeloid leukemia: a case report. Transfusion, 45:1735-38, 2005. Cover picture on journal PMID: 16271098 
35. Agrawal YP. Low dose naltrexone therapy in multiple sclerosis. Med Hypotheses, 64: 721-4, 2005. PMID: 15694688 
36. Letters to the editor: Agrawal YP. Possible importance of antibiotics and naltrexone in neurodegenerative disease. Eur J Neurol, 2006, 13(9):e7. PMID: 16930351 
37. Letters to the editor: Lueck N, Agrawal YP. Lack of utility of free light chain 
specific antibodies in the urine immunofixation test. Clinical Chemistry, 5:906-7, 2006. PMID: 16638965 
38. Peerschke EIB, Agrawal Y, Alexander CB, Bovill E, Laposata M. Proposed Research Training Guidelines for Residents in Laboratory Medicine. Clin Lab Med 27:241-253, 2007. PMID: 17556083 
39. Tomer M, Jayabalan D, Coleman M, Pearse RN, Wang YL, Lent R, Christos PJ, Lee JW, Agrawal YP, Matthew S, Ely S, Mazumdar M, Cesarman E, Leonard JP, Furman RR, Chen-Kiang S, Niesvizky R. Atypical serum immunofixation patterns frequently emerge in immunomodulatory therapy and are associated with a high degree of response in multiple myeloma. Br J Haematol. 143(5):654-60, 2008. PMID: 18950461 
40. Salemi Arash, Agrawal YP, Fontes MA. An Assay to Monitor Bivalirudin Levels in Cardiopulmonary Bypass. Ann Thoracic Surgery, 92:332-4, 2011. PMID: 21718867 
41. Letters to the Editor: Carmel Ralph, Agrawal YP. Failures of cobalamin assays in pernicious anemia. New Engl J Med 367:385-386, 2012. PMID: 22830482 
42. Carmel Ralph, Agrawal YP. Additional correspondence to above: More on failures of cobalamin assays in pernicious anemia. New Engl J Med 367:1571, 2012. PMID: same as previous 
43. Agrawal YP, Rennert H. Pharmacogenomic testing of toxicological drugs. Clinics in Laboratory Medicine 32:509-523, 2012. PMID: 22939305 
44. Agrawal YP, Cid M, Westgard S, Parker T, Jaikaran R, Levine D. Transplant Patient Classification and Tacrolimus Assays: More Evidence of the Need for Assay Standardization. Ther Drug Monit 36:706-9, 2014. PMID: 24784024 
45. Cohen R, Lata JP, Lee Y, Hernández JC, Nishimura N, Schaffer CB, Mukai C, Nelson JL, Brangman SA, Agrawal Y, Travis AJ. Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection. PLoS One. 2015 Nov 25;10(11): e0142326. PMID: 26605916 
46. Agrawal Y, Hall K. Laboratory Reflections: The Lipemia Index an Underutilized Tool to Detect Monoclonal Proteins. Journal of Applied Laboratory Medicine, in press, 2019 

Books and other publications:
47. Agrawal YP, Lewandrowski K. Laboratory diagnosis of disorders of the thyroid. Clinical Chemistry: Laboratory Management and Clinical Correlations, Lewandrowski K. ed. Lippincott Williams & Wilkins, p.592-605, 2002 
48. Agrawal YP, Lewandrowski K. Laboratory evaluation of pituitary, adrenal glands and selected neuroendocrine tumors. Clinical Chemistry: Laboratory Management and Clinical Correlations, Lewandrowski K. ed. Lippincott Williams & Wilkins, p.606-624, 2002. 
49. Agrawal YP, Saidman SL. Histocomptability Testing and Transplantation.Laboratory Medicine: Clinical Pathology in the Practice of Medicine. Laposata M. ed. ASCP Press, p.115-122, 2002. 
50. Arinsburg S, Agrawal YP. Can high-sensitivity C-reactive protein measurements replace the time-honored erythrocyte sedimentation rate? Q & A, CAP Today, 3:99, 2009 
51. Agrawal YP. Critical values for therapeutic drug levels. Medical Laboratory Observers CLR: 42:10, 2010, 2011, 2012, 2013 http://www.clr-online.com/CLR201213-Table-of-Critical-Values.pdf 
52. Agrawal YP, Saidman SL. Histocomptability Testing and Transplantation. Laboratory Medicine:The Diagnosis of Disease in the Clinical Laboratory. Laposata M. 1st ed. McGraw Hill Medical, p.67-73, 2010. Italian edition 2013. 
53. Hawker CD, Agrawal Y, Balis UJ, Catalasan IM, Charache P, Vantu QH, Wagar EA. Specimen Labels:Content and Location, Fonts, and Label Orientation; Approved Standard. CLSI 31:7, p.1-37, 2011. 
54. Agrawal, YP. Pharmacokinetic concepts in toxicology and therapeutic drug monitoring. Magnani and Bissell, ed. CAP Press, p 221-227, 2012. 
55. Agrawal, YP. Pharmacogenomics Essentials Program. Pharmacokinetics and Pharmacodynamics Underlying Pharmacogenomic Testing (SAM eligible) © 2012 College of American Pathologists - Online CME Self Assessment Module released September, 2012 
56. Agrawal, YP. 8 different Endocrinology topics. In: Clinical Decision Support System. Alter, Melanson and Laposata, eds 2012. Electronic access at DECISIONSUPPORTINMEDICINE.COM Note: Website is no longer active 
57. Agrawal YP, Saidman SL. Histocomptability Testing and Transplantation. Laboratory Medicine:The Diagnosis of Disease in the Clinical Laboratory. Laposata M. 2nd ed. McGraw Hill Medical, p.83-90, 2014. 
58. Agrawal YP, Sheshadri Narayanan. Preanalytical variables in therapeutic drug monitoring. In: Pre-Examination Procedures in Laboratory Diagnostics. W.Gudel, S Narayanan, Eds. DeGruyter, p.305-317, 2015 
59. Agrawal, YP. Pharmacokinetic concepts in toxicology and therapeutic drug monitoring. Magnani and Wu, eds. In: Clinical Toxicology Testing. CAP Press, in press, 2019. 
60. Furmaga W, Agrawal YP. Method Validation in Toxicology. Magnani and Wu eds. In: Clinical Toxicology Testing. CAP Press, in press, 2019. 
61. The College of American Pathologists Position Statement: Pathologist role in confronting the opioid crisis. Approved guideline, CAP Board of Governors. 2018