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Samuel P. Gubbels MD, FACS

Associate Professor


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Samuel Paul Gubbels, MD, is an Associate Professor in the Department of Otolaryngology. He recently joined the University of Colorado after a seven year period as a faculty member at the University of Wisconsin – Madison. Dr. Gubbels has a specialty clinical practice dedicated to managing hearing loss, balance disorders and diseases of the skull base. In addition, he runs a research program focused on evaluating stem cells as a means to better understand and treat hearing loss in humans. Hearing loss is an exceedingly common problem worldwide with severe to profound deafness affecting over 300 million individuals worldwide. 

Dr. Gubbels’ lab is interested in using a variety of stem cell types to model the development, disease and regeneration of inner ear hair and supporting cells in vitro. His research focuses on defining a method to reliably direct the differentiation of human pluripotent stem cells into auditory hair cells and other inner ear cell types. In addition, he seeks to evaluate the ability of these cells to integrate into the appropriate areas of the inner ear upon transplantation by using a novel, developmental in vivo model system. In addition, his research uses a number of transgenic mouse models to evaluate the persistence of a population of stem cell-like cells in the adult mammalian cochlea. 

In addition to his basic and translational research interests, Dr. Gubbels is involved in a variety of clinical research projects. Areas of particular interest are in imaging of cochlear implants, hearing preservation in cochlear implantation and skull base surgery, and cochlear implant indications. 

Hiroki Takeda, MD, Post-doctoral Fellow

Jessica Randall, MS

Anna Dondzillo, PhD, University of Colorado, Department of Otolaryngology

Richard JH Smith, MD, University of Iowa, Department of Otolaryngology​

Dr. Gubbels currently has an R01 from the NIH/NIDCD to support his research program. He has previously had an R03 from the NIH/NIDCD as well as a KL2 career development award from the Institute for Clinical and Translational Research at the University of Wisconsin. Prior to this Dr. Gubbels was awarded a research fellowship from the American Otological Society and a resident research award from the AAO-NHS. ​