12700 E. 19th Avenue
Mail Stop #8606
Aurora, CO 80045
Dr. Regie Santos-Cortez is an Associate Professor performing
basic research in the Department of Otolaryngology. Her R01-funded project aims to identify novel genes and variants that are involved in susceptibility to otitis media and changes in the middle ear microbiome. This project has a collection of DNA samples and sequence data including exomes from >1,000 families and patients from the US, Philippines and Finland, as well as middle ear tissues and swabs and data from multiple head and neck sites for microbiome studies. Recently the lab has collected DNA, RNA and microbial samples from collaborating otologists and pediatric otolaryngologists within the Department and submitted samples for sequencing and analyses. These multi-omic studies allow for data integration that leads to a deeper understanding of otitis media pathophysiology, and hopefully in the future this knowledge may lead to improved management of otitis media. The collaborative network supporting this project involves investigators from multiple US and international institutions who not only provide clinical data and samples for study but also contribute clinical, genetic and statistical expertise to the project.