Upper Airway Disorders Lab
Marie Jetté, PhD, CCC-SLP
the Lab’s Work
The larynx is a
special organ that functions as both a valve to protect the airway and as a
biomechanical vibrator to produce voice. Prolonged irritation of the laryngeal
mucosa leads to inflammation and difficulties with vital laryngeal functions
including voice, swallow, and respiration. My broad
research interest is identifying the pathophysiology of laryngeal inflammation
in patients with voice disorders, upper airway dyspnea, and chronic cough.
Structure and Function of Chemical Receptors in the
One area of
research focus is characterizing chemical receptors in the laryngeal epithelium
including solitary chemosensory cells, taste buds, and polymodal nociceptive
nerve fibers. We are specifically interested in how stimulation of chemical
receptors may result in local inflammation via a neurogenic pathway. This
research is a collaboration with Dr. Thomas Finger in Cell and Developmental
Biology, Dr. Sue Kinnamon in Otolaryngology, and Drs. Matthew Clary and Jeremy
Prager, otolaryngologists in our department.
research in Laryngology spans a broad range of topics related to patient
outcomes and evaluation of new diagnostic technologies. Clinical research
collaborators include Drs. Matthew Clary and Daniel Fink of Otolaryngology and
Dr. Rena Yadlapati of Gastroenterology and Hepatology.