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Our mission is to provide outstanding, cutting-edge clinical care, research, and state-of-the-art training in Otolaryngology

Department of Otolaryngology
 

Sue C. Kinnamon, PhD

Professor


Sue Kinnamon

 

Research Lab:

Chemosensory Transduction Laboratory


Contact:

12700 E 19th Avenue, MS 8606
Aurora, CO 80045

Phone: 303-724-3075
Fax: 303-724-4553
Email: Sue.Kinnamon@ucdenver.edu


 

 

 

 

 

 

 

 

(1971) MS, Zoology, University of Massachusetts, Amherst, MA

(1982) PhD, Biology, Neuroscience concentration, Kansas State University, Manhattan, KS

Postdoctoral Education

(1981-1983) Postdoctoral, W. Betz, Department of Physiology, University of Colorado School of Medicine, Denver, CO

(1984-1985) Postdoctoral, S. Roper, Department of Anatomy, University of Colorado School of Medicine, Denver, CO

April, 2001 - Outstanding Achievement Award, Association for Chemoreception Sciences 

Vandenbeuch, A., Zorec, R., and Kinnamon, S.C. (2010). Capacitance measurements of regulated exocytosis in mouse taste cells. J. Neuroscience, 30(44):14695-701.

Vandenbeuch, A., Tizzano, M., Anderson, C.B., Stone, L.M., Goldberg, D. and Kinnamon, S.C. (2010). Evidence for a role of glutamate as an efferent transmitter in taste buds. BMC Neuroscience. 21:77

Tizzano, M., Gulbransen, B.D., Vandenbeuch, A., Clapp, T.R., Herman, J.P., Sibhatu, H.M., Churchill, M.E.A., Silver, W.L., Kinnamon, S.C., and Finger, T.E. (2009). Nasal chemosensory cells utilize bitter taste signalling to detect irritants and pathogenic Bacteria. PNAS 107:3210-5.

Clapp, T., Trubey, K., Vandenbeuch, A., Stone, L.M., Margolskee, R.F., Chaudhari, N. and Kinnamon, S.C. (2008). Tonic activity of a-gustducin regulates taste cell responsivity. FEBS Letters, 582(27):3783-7. 16. Pub Med ID: 18930056

Gulbransen, B., Clapp, T., Finger, T.E., and Kinnamon, S.C. (2008). Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitro. J. Neurophysiol., 99:2929-37. Pub Med ID: 18417634

Vandenbeuch, A., Clapp, T. R., and Kinnamon, S.C. (2008). Amiloride-sensitive channels in type I fungiform taste cells in mouse. BMC Neurosci 9:1-13. Pub Med ID: 18171468

Stone, L. M., Barrows, J., Finger, T. E., and Kinnamon, S.C. (2007). Expression of T1Rs and gustducin in palatal taste buds of mice. Chem Senses 32:255-262. Pub Med ID: 17229761

Trubey, K. R., Culpepper, S., Maruyama, Y., Kinnamon, S.C., and Chaudhari, N. (2006). Tastants evoke cAMP signal in taste buds that is independent of calcium signaling. Am J Physiol Cell Physiol 291:C237-244. Pub Med ID: 16510847

Clapp, T. R., Medler, K. F., Damak, S., Margolskee, R. F., and Kinnamon, S.C. (2006). Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25. BMC Biol 4:7. Pub Med ID: 16573824

Silver, W. L., Clapp, T. R., Stone, L. M., and Kinnamon, S.C. (2006). TRPV1 receptors and nasal trigeminal chemesthesis. Chem Senses 31:807-812. Pub Med ID: 16908491

Ruiz, C., Gutknecht, S., Delay, E., and Kinnamon, S. (2006). Detection of NaCl and KCl in TRPV1 knockout mice. Chem Senses 31:813-820. Pub Med ID: 16923776

Finger, T. E., Danilova, V., Barrows, J., Bartel, D. L., Vigers, A. J., Stone, L., Hellekant, G., and Kinnamon, S.C. (2005). ATP signaling is crucial for communication from taste buds to gustatory nerves. Science 310:1495-1499. Pub Med ID: 16322458

Clapp, T. R., Yang, R., Stoick, C. L., Kinnamon, S.C., and Kinnamon, J. C. (2004). Morphologic characterization of rat taste receptor cells that express components of the phospholipase C signaling pathway. J Comp Neurol 468:311-321. Pub Med ID: 14681927

Lin, W., Burks, C. A., Hansen, D. R., Kinnamon, S.C., and Gilbertson, T. A. (2004). Taste receptor cells express pH-sensitive leak K+ channels. J Neurophysiol 92:2909-2919. Pub Med ID: 15240769

Lin, W., Ogura, T., and Kinnamon, S.C. (2003). Responses to di-sodium guanosine 5'-monophosphate and monosodium L-glutamate in taste receptor cells of rat fungiform papillae. J Neurophysiol 89:1434-1439. Pub Med ID: 12626621.

Medler, K. F., Margolskee, R. F., and Kinnamon, S.C. (2003). Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice. J Neurosci 23:2608-2617. Pub Med ID: 12684446

Ruiz, C. J., Wray, K., Delay, E., Margolskee, R. F., and Kinnamon, S.C. (2003). Behavioral evidence for a role of alpha-gustducin in glutamate taste. Chem Senses 28:573-579. Pub Med ID: 14578119

Ogura, T., Margolskee, R. F., and Kinnamon, S.C. (2002). Taste receptor cell responses to the bitter stimulus denatonium involve Ca2+ influx via store-operated channels. J Neurophysiol 87:3152-3155. Pub Med ID: 12037215

Lin, W., Ogura, T., and Kinnamon, S.C. (2002). Acid-activated cation currents in rat vallate taste receptor cells. J Neurophysiol 88:133-141. Pub Med ID: 12091539

Stone, L. M., Wilcox, C. L., and Kinnamon, S.C. (2002). Virus-mediated transfer of foreign DNA into taste receptor cells. Chem Senses 27:779-787. Pub Med ID: 12438203

Clapp, T. R., Stone, L. M., Margolskee, R. F., and Kinnamon, S.C. (2001). Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction. BMC Neurosci 2:6. Pub Med ID: 11346454

Varkevisser, B., Peterson, D., Ogura, T., and Kinnamon, S.C. (2001). Neural networks distinguish between taste qualities based on receptor cell population responses. Chem Senses 26:499-505. Pub Med ID: 11418495

Ruiz, C. J., Stone, L. M., McPheeters, M., Ogura, T., Bottger, B., Lasher, R. S., Finger, T. E., and Kinnamon, S.C. (2001). Maintenance of rat taste buds in primary culture. Chem Senses 26:861-873. Pub Med ID: 11555481

Varkevisser, B., and Kinnamon, S.C. (2000). Sweet taste transduction in hamster: role of protein kinases. J Neurophysiol 83:2526-2532. Pub Med ID: 10805654

Lin, W., and Kinnamon, S.C. (1999). Physiological evidence for ionotropic and metabotropic glutamate receptors in rat taste cells. J Neurophysiol 82:2061-2069. Pub Med ID: 10561387

Ogura, T., and Kinnamon, S.C. (1999). IP(3)-Independent release of Ca(2+) from intracellular stores: A novel mechanism for transduction of bitter stimuli. J Neurophysiol 82:2657-2666. Pub Med ID: 10561435

Lin, W., and Kinnamon, S.C. (1999). Co-localization of epithelial sodium channels and glutamate receptors in single taste cells. Biol Signals Recept 8:360-365. Pub Med ID: 10592378

Wladkowski, S. L., Lin, W., McPheeters, M., Kinnamon, S.C., and Mierson, S. (1998). A basolateral chloride conductance in rat lingual epithelium. J Membr Biol 164:91-101. Pub Med ID: 9636247

Lin, W., and Kinnamon, S.C. (1998). Responses to monosodium glutamate and guanosine 5'-monophosphate in rat fungiform taste cells. Ann N Y Acad Sci 855:407-411. Pub Med ID: 9929633

Delay, R. J., Kinnamon, S.C., and Roper, S. D. (1997). Serotonin modulates voltage-dependent calcium current in Necturus taste cells. J Neurophysiol 77:2515-2524. Pub Med ID: 9163373

Ogura, T., Mackay-Sim, A., and Kinnamon, S.C. (1997). Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus. J Neurosci 17:3580-3587. Pub Med ID: 9133381

Bigiani, A., Delay, R. J., Chaudhari, N., Kinnamon, S.C., and Roper, S. D. (1997). Responses to glutamate in rat taste cells. J Neurophysiol 77:3048-3059. Pub Med ID: 9212256

Kossel, A. H., McPheeters, M., Lin, W., and Kinnamon, S.C. (1997). Development of membrane properties in taste cells of fungiform papillae: functional evidence for early presence of amiloride-sensitive sodium channels. J Neurosci 17:9634-9641. Pub Med ID: 9391018

Mackay-Sim, A., Delay, R. J., Roper, S. D., and Kinnamon, S.C. (1996). Development of voltage-dependent currents in taste receptor cells. J Comp Neurol 365:278-288

Cummings, T. A., Daniels, C., and Kinnamon, S.C. (1996). Sweet taste transduction in hamster: sweeteners and cyclic nucleotides depolarize taste cells by reducing a K+ current. J Neurophysiol 75:1256-1263. Pub Med ID: 8867134

Bowerman, A. G., and Kinnamon, S.C. (1994). The significance of apical K+ channels in mudpuppy feeding behavior. Chem Senses 19:303-315. Pub Med ID: 7812724

McPheeters, M., Barber, A. J., Kinnamon, S.C., and Kinnamon, J. C. (1994). Electrophysiological and morphological properties of light and dark cells isolated from mudpuppy taste buds. J Comp Neurol 346:601-612. Pub Med ID: 7983246

Gilbertson, T. A., Roper, S. D., and Kinnamon, S.C. (1993). Proton currents through amiloride-sensitive Na+ channels in isolated hamster taste cells: enhancement by vasopressin and cAMP. Neuron 10:931-942. Pub Med ID: 8388226

Cummings, T. A., Powell, J., and Kinnamon, S.C. (1993). Sweet taste transduction in hamster taste cells: evidence for the role of cyclic nucleotides. J Neurophysiol 70:2326-2336. Pub Med ID: 8120585

Kinnamon, S.C. (1992). Role of K+ channels in taste transduction. Soc Gen Physiol Ser 47:261-270. Pub Med ID: 1369766

Cummings, T. A., and Kinnamon, S.C. (1992). Apical K+ channels in Necturus taste cells. Modulation by intracellular factors and taste stimuli. J Gen Physiol 99:591-613. Pub Med ID: 1597680

Gilbertson, T. A., Avenet, P., Kinnamon, S.C., and Roper, S. D. (1992). Proton currents through amiloride-sensitive Na channels in hamster taste cells. Role in acid transduction. J Gen Physiol 100:803-824. Pub Med ID: 1335477

Kinnamon, S.C., Cummings, T. and Roper, S.D. (1988). Isolation of single taste cells from lingual epithelium. Chem. Senses 13, 355-366.

Kinnamon, S.C. and Roper, S.D.(1988). Evidence for a role of voltage-sensitive apical K+ channels in sour and salt taste transduction. Chemical Senses 13, 115-121.

Kinnamon, S.C., and Roper, S. D. (1988). Membrane properties of isolated mudpuppy taste cells. J Gen Physiol 91:351-371 Pub Med ID: 2454284

Kinnamon, S.C., Dionne, V. E., and Beam, K. G. (1988). Apical localization of K+ channels in taste cells provides the basis for sour taste transduction. Proc Natl Acad Sci U S A 85:7023-7027. Pub Med ID: 2457924

Kinnamon, S.C., and Roper, S. D. (1987). Passive and active membrane properties of mudpuppy taste receptor cells. J Physiol 383:601-614. Pub Med ID: 2443655

Kinnamon, S.C., Betz, W. J., and Caldwell, J. H. (1985). Development of a steady electric current in neonatal rat lumbrical muscle. Dev Biol 112:241-247 Pub Med ID: 4054435

Betz, W. J., Caldwell, J. H., and Kinnamon, S.C. (1984). Physiological basis of a steady endogenous current in rat lumbrical muscle. J Gen Physiol 83:175-192. Pub Med ID: 6325581

Kinnamon, S.C., Kammer, A.E. and Kiorpes, A.L. (1984). Neural control of ventilatory movements in the aquatic insect Corydalus cornutus: central effect of hypoxia. Physiol. Entomol. 9, 19-28.

Kinnamon, S.C., Klaassen, L. W., Kammer, A. E., and Claassen, D. (1984). Octopamine and chlordimeform enhance sensory responsiveness and production of the flight motor pattern in developing and adult moths. J Neurobiol 15:283-293. Pub Med ID: 6090587

Betz, W. J., Caldwell, J. H., and Kinnamon, S.C. (1984). Increased sodium conductance in the synaptic region of rat skeletal muscle fibres. J Physiol 352:189-202. Pub Med ID: 6747888

Kinnamon, S.C. and Kammer, A.E. (1983). Neural control of ventilatory movements in the aquatic insect Corydalus cornutus: the motor pattern. J. comp. Physiol. 153, 543-555.

Kammer, A.E. and Kinnamon, S.C. (1979). Maturation of the flight motor pattern without movement in Manduca sexta. J. comp. Physiol. 130, 29-37.

Kammer, A.E. and Kinnamon, S.C. (1977). Patterned muscle activity during eclosion in the hawkmoth Manduca sexta. J. comp. Physiol. 114, 313-326.

Research Lab:
Chemosensory Transduction Laboratory

Research Focus:

  • Physiology of taste transduction
  • Neurotransmitters in taste cells
  • Nasal solitary chemoreceptor cells - role in detection of irritants and pathogenic bacteria

Society for Neuroscience
Association for Chemoreception Sciences
Physiological Society
Faculty of 1000
College of CSR Reviewers