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Department of Orthopedics

Department of Orthopedics
 

Research Opportunities

Orthopedic Surgery Interest Group


​​Below you will find research opportunities listed in REDCap that are currently open for students to participate in. Please browse each one of the  divisional tabs and click on the title of the study to submit an inquiry. Each submission will be evaluated and you will be contacted when matched. For more information on research studies, please contact Frank Scott, MD.

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​Title of Study ​Principal Investig​ator ​Description
 
Evalina Burger, MD The primary hypothesis is cell saver transfusion in spine surgery is associated with coagulation abnormalities or other changes in the body.

Melatonin/Calmodulin Signaling- AIS

​Evalina Burger, MD
​Melatonin/Calmodulin Signaling- AIS
 
Medicrea Adult Deformity Study ​Evalina Burger, MD
​The purpose of this study is to evaluate the correlation between the restoration of the sagittal balance and the improvement of the quality of life for patients with adult scoliosis, treated with a polyaxial system (PASS® LP system) during the 2 years after a spinal fusion surgery.
 
Christopher Cain, MD The objective of this retrospective study is to evaluate the positioning of disk replacement devices in total disc replacement (TDR) procedures. Using a finite element model (FEM), actual positioning of disk replacement devices will be compared to ideal placement as determined by FEM.  The correlation between actual and ideal placement will then be related to the clinical outcomes to assess the importance of precise device positioning in the TDR procedures.

Michael Finn In the present study, we plan to build on the initial description of the prevalence of medical marijuana use in a university spine center that we have researched previously through the use of a survey.

​Marijuana and Spine Pain ​Michael Finn ​An increasing number of patients presenting for spinal surgery evaluation at the University of Colorado Spine center have been noted to be using marijuana for the treatment of their condition by the investigators. The purpose of this study is to examine medical marijuana usage rates in patients presenting for surgical evaluation in a tertiary spinal surgery clinic. Secondary aims are to investigate potential relationships between marijuana use and clincal status on 2 standard questionnaires. 

Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects with Acute Spinal Cord Injury

​Susan Ladley-O'Brien ​A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects with Acute Spinal Cord Injury
Denver SI Joint Questionnaire (DSIJQ) Validation Study ​Emily Lindley, PhD The Oswestry Disability Index (ODI) is one of the most commonly used and reported clinical outcome measures.  Although the ODI has been validated for patients with chronic LBP, it has not been validated in SI joint pain. 

HCOL ​Emily Lindley, PhD ​The overall purpose of this study is to create a prospective database that will allow us to (1) track outcomes following various spine surgery procedures and (2) identify potential demographic and psychosocial predictors of outcomes.  We will administer several demographic, functional, and psychosocial questionnaires to patients before their scheduled spine surgery and at 3, 6, 12, and 24 months postoperative.  

​Pain Preception Study Vikas Patel, MD​
​The present research proposal will build upon these findings and overcome their limitations by developing and evaluating a computer controlled pressure instrument. This novel instrument will be designed to measure pressure output with greater sensitivity and produce stimuli with higher inter-stimulus reliability than currently available hand-held pressure instruments. Furthermore, the instrument will simultaneously record changes in heart rate, skin impedance, and blood pressure during the pain testing, as these autonomic responses have recently been linked to pain sensitivity. The instrument will be used in the present study to test pain thresholds and tolerance in healthy individuals to establish normative data.

​Prospective O-Arm Study Vikas Patel, MD​
​Techniques for pedicle screw placement have included the use of anatomic landmarks, laminotomy with palpation of the pedicle, plain radiography, standard fluoroscopic imaging, fluoroscopic image guidance, and computed tomography (CT) image guidance.

Vitamin D Deficiency in Rats Vikas Patel, MD​ ​The goal of this study is to investigate the effect of vitamin D deficiency on the success of spinal fusion.

Retro 3D SI Imaging Vikas Patel, MD​ The objective of this retrospective study is to determine the various characteristics of the sacroiliac joint, including surface area, shape, articular cartilage surface area, symphyseal surface area, and 3D cross-sectional imaging anatomy of the sacroiliac joint.​

VertiFlex Superion Interspinous Spacer Vikas Patel, MD​
The proposed prospective, multi-center, randomized clinical trial is designed to evaluate the safety and effectiveness of the Superion™ ISS compared to the X-STOP® IPD® device in healthy adults suffering from at least 6 months of moderate spinal stenosis symptoms who have been unresponsive to conservative care.
INSITE Vikas Patel, MD​ ​The purpose of this study is to compare outcomes when patients with degenerative sacroiliitis (arthritis of the SI joint) and or sacroiliac disruption (abnormal separation or tearing of the sacroiliac joint)undergo either SI joint fusion with the iFuse Implant System or undergo specific, targeted non-surgical treatment of the SI joint.

Aesculap Activ-L Vikas Patel, MD​

​The purpose of this study is to learn whether an investigational device called the Activ-L Artificial Disc is safe and effective in the treatment of degenerative disc disease of the lumbar spine.

​LANX Aspen Study​ Vikas Patel, MD ​This is a multi-center, prospective randomized clinical study to evaluate the clinical outcome of subjects with degenerative disc disease (DDD) treated with ALIF and supplemental posterior fixation using ASPEN Spinous Process System compared to pedicle screw instrumentation.

 
​Title of Study​ ​Principal Investigator ​Decription
Lateral Meniscus Root Tear in ACL​ ​Jonathan Bravman, MD ​Chart review 2008-present of AV & JB ACLs. No ICF.

Eric McCarty, MD
ACL Hybrid graft reconstruction vs HS Autograft. Chart review, questionnaire on REDCap.
 
CU Sports Medicine Outcomes Registry Eric McCarty, MD​
Proximal Biceps tenotomy versus tenodesis Eric McCarty, MD​
​FELLOWS 2010-2011 STUDY Patients ID'ed though chart review. Research student did a physical exam plus questionnaire administration.
 
 
Eric McCarty, MD​ ​Multi-center study based out of Emory Univ. Retrospective chart review.
​Return to Sport After Anterior Shoulder Stabilization 
​Chart review. Questionnaire follow-up study for return to sport for patients who underwent Anterior Shoulder Stabilization with ECM.
 
Game Ready Eric McCarty, ​MD​
​2 week post RCR surgery. Randomized, x-over, GameReady vs Ice Bags and narcotic demand after shoulder arthroscopy. Assigned to CC/IW or IW/CC. Pt diary, SF-12 at ~ day 10.
 
Histogenics NeoCart Eric McCarty, ​MD​ ​CCT for autologous cell matrix for repair of cartilage defects of the lateral or medial femoral condyle.

MOON Shoulder Instability Eric McCarty, ​MD​ ​Multi-center prospective longitudinal study to determine predictors of failure & poor patient reported outcomes following surgery on the capsule or labrum for shoulder instability and/or pain. Ages 13-up. Initial (on site), 2/6/10/20 year (Iowa sends & collects) questionnaires only non-SOC procedures. Surgeons to complete CRFs & distribute post-op & PT booklets. Site sends itinial and 4-6 month packets to Iowa.

MOON Shoulder Rehab​ Eric McCarty, ​MD​ ​Pt history and physical exam & pt questionniares. PT 3x WEEK for 6 week, diary, then 6 week post - questionnaires. Vanderbilt LTFU follow-up at 1, 2, 5, 7, and 10 years.

MOON Shoulder IMPACT Eric McCarty, ​MD​ ​RCR surgery, randomly assigned to PT 2 weeks or 6 weeks post-op and then followed for 1 year with an MRI at the 52 week mark.

MTF Eric McCarty, ​MD​ ​Retrospective comparison of suture anchors used in shoulder surgery (at least 2 years post-surgery).

MOON Knee/MARS Eric McCarty, ​MD​ ​MOON Knee (First time ACL repair) => 5xxxx, data sent to Vanderbilt, 2007-2008, Vanderbilt enrollment ended 12/2008. MOON Knee (9xxxx) => 2009-20011, same data collected, Colorado data only (not sent to V). MARS (revision ACL), 5-xxxx, 2007-final enroll, data sent to Vanderbilt. Questionnaires at 2, 6, & 10 years.

​Shoulder Surveys Eric McCarty, ​MD​ ​Paper or online surveys for long term follow up of patients who have been evaluated or treated for a shoulder injury. Three arms: Osteoarthritis; Shoulder Instability; Rotator Cuff.

Hip and Lower Extremity Outcomes Registry

Omer Mei-Dan, MD ​Hip and Lower Extremity Outcomes Registry
PRP vs HA in Hip OA​ Omer Mei-Dan, MD ​A Randomized Clinical Trial Evaluating Platelet Rich Plasma versus Hyaluronic-Acid in the short-term Treatment of Symptomatic OA (Osteoarthritis) of the Hip
 
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​Title of Study ​Principal Investig​ator ​Description

David Hak, MD ​Study of AMG 785 in Skeletally Mature Adults with a Fresh Unilateral Tibial Diaphyseal Fracture Status Post Definitive Fracture Fixation with an Intramedullary Nail
A Retrospective Study of the Treatment of Long Bone Defects (RetroDEFECT)

David Hak, MD
A Retrospective Study of the Treatment of Long Bone Defects (RetroDEFECT) 
Assessment of Fixation Strategies for Severe Open Tibia Fractures (FIXIT)

David Hak, MD
​Assessment of Fixation Strategies for Severe Open Tibia Fractures (FIXIT)
 
 
David Hak, MD
Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage: Correlation with Subsequent Post-Closure Deep Wound Infection (Bioburden Study)
 
David Hak, MD Improving Activity and Quality of Life Following Lower Extremity Trauma: The Trauma Collaborative Care Study (TCCS)
Major Extremity Trauma Research Consortium (METRC) Registry

David Hak, MD
Major Extremity Trauma Research Consortium (METRC) Registry
Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage vs. Transtibial Amputation Protocol (OUTLET Study)

David Hak, MD ​Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage vs. Transtibial Amputation Protocol (OUTLET Study)
Predicting Acute Compartment Syndrome (PACS) using Optimized clinical Assessment, Continuous Pressure Monitoring, and Continuous Tissue Oximetry

David Hak, MD ​Predicting Acute Compartment Syndrome (PACS) using Optimized clinical Assessment, Continuous Pressure Monitoring, and Continuous Tissue Oximetry
RhBMP-2 vs. Autograft for Critical Size Tibial Defects: a multicenter, randomized trial (pTOG)​

David Hak, MD ​RhBMP-2 vs. Autograft for Critical Size Tibial Defects: a multicenter, randomized trial (pTOG)
Treatment of Acetabular Fractures and their Outcomes among Older Adults Admitted to Level 1 Trauma Centers: A Retrospective Data Review

David Hak, MD ​Treatment of Acetabular Fractures and their Outcomes among Older Adults Admitted to Level 1 Trauma Centers: A Retrospective Data Review
Challenges and Complications Associated With The Use of Balloon Inflation-Plasty For The Treatment of Tibial Plateau Fractures

Cyril Mauffrey, MD​ ​Challenges and Complications Associated With The Use of Balloon Inflation-Plasty For The Treatment of Tibial Plateau Fractures
Epidemiology of Pelvic Fractures

Cyril Mauffrey, MD ​Epidemiology of Pelvic Fractures
​Resuscitation vs. Early External Fixation as Initial Management of Long-Bone Fractures in the Hyperacute Setting

Cyril Mauffrey, MD ​Resuscitation vs. Early External Fixation as Initial Management of Long-Bone Fractures in the Hyperacute Setting
Retrospective Review of Compartment Syndrome In Orthopaedic Traumatology

Cyril Mauffrey, MD ​Retrospective Review of Compartment Syndrome In Orthopaedic Traumatology
Retrospective Study of OTA Classification for Open Fractures

Cyril Mauffrey, MD ​Retrospective Study of OTA Classification for Open Fractures
Trial of Inflation Osteoplasty in the Management of Tibial Plateau Fractures

Cyril Mauffrey, MD ​Trial of Inflation Osteoplasty in the Management of Tibial Plateau Fractures
Defining the Safe Timing and Modality of Femur Shaft Fracture Fixation in Head-Injured Patients​

​Philip Stahel, MD ​Defining the Safe Timing and Modality of Femur Shaft Fracture Fixation in Head-Injured Patients
 
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​Title of Study ​Principal Investig​ator ​Description
 
James Carollo, PhD ​Impact of spinal FusionConstruct w/Saropelvic Fixation on Gait Dynamics
Rhythmic Auditory Stimulation in Gait Training for Children with Cerebral Palsy (RAS)

James Carollo, PhD
Rhythmic Auditory Stimulation in Gait Training for Children with Cerebral Palsy (RAS) 
Validation of Automated Computer Algorithm for Detecting Heel-Off and Foot Positions during Walking

James Carollo, PhD
Validation of Automated Computer Algorithm for Detecting Heel-Off and Foot Positions during Walking 
 
James Carollo, PhD Inter-Segmental Coordination and Ankle-foot Orthoses during Gait by Children with Spastic Cerebral Palsy
 
​Frank Chang, MD Correction of Ankle Valgus Deformity in Children Using Medial Tibia Hemiepiphysiodesis
Effect of Adapted Skiing and Snowboarding on the Motor Function and Endurance of Children with Physical Disabilities

Frank Chang, MD Effect of Adapted Skiing and Snowboarding on the Motor Function and Endurance of Children with Physical Disabilities
Effects of Adapted Skiing and Snowboarding on Quality of Life of Children with Physical Disabilities

Frank Chang, MD ​Effects of Adapted Skiing and Snowboarding on Quality of Life of Children with Physical Disabilities
Outcomes of the Evans Calcaneal Lengthening Osteotomy

Frank Chang, MD ​Outcomes of the Evans Calcaneal Lengthening Osteotomy
​Acetabular and Femoral Development Before and After a Varus Derotational Osteotomy in Children with Cerebral Palsy

Frank Chang, MD ​Acetabular and Femoral Development Before and After a Varus Derotational Osteotomy in Children with Cerebral Palsy
Comparison of Graft Material used in the Evans Calcaneal Lengthening in Children with Cerebral Palsy

Frank Chang, MD ​Comparison of Graft Material used in the Evans Calcaneal Lengthening in Children with Cerebral Palsy
Outcomes Comparison Of Proximal Tibial Epiphysiodesis With Or Without Concomitant Proximal Fibular Epiphysiodesis​

Frank Chang, MD ​Outcomes Comparison Of Proximal Tibial Epiphysiodesis With Or Without Concomitant Proximal Fibular Epiphysiodesis
​Treatment of supracondylar humerus fractures at Children's Hospital Colorado and determine factors that are predictive for the need of open reduction.

​De Sayan ​The purpose of this study is to describe the treatment of supracondylar humerus fractures at Children's Hospital Colorado and determine factors that are predictive for the need of open reduction.
Chest Wall Dynamics Assessment Using Motion Capture

Mark Erickson, MD ​Chest Wall Dynamics Assessment Using Motion Capture
​Fox Pediatric Spinal Deformity Study

Mark Erickson, MD ​Fox Pediatric Spinal Deformity Study
Impact of VEPTR surgery on chest wall dynamics

Mark Erickson, MD ​Impact of VEPTR surgery on chest wall dynamics
​Intraoperative and Postoperative LIV-Tilt and Disc Wedging in Patients with AIS: Is There a Correlation?​

Mark Erickson, MD ​Intraoperative and Postoperative LIV-Tilt and Disc Wedging in Patients with AIS: Is There a Correlation?
Minimize Implants Maximize Outcomes (MIMO) Clinical Trial

Mark Erickson, MD ​Minimize Implants Maximize Outcomes (MIMO) Clinical Trial
Prospective Pediatric Scoliosis Study

Mark Erickson, MD ​Prospective Pediatric Scoliosis Study
The Development/Implemenation of the Aristotle Spine Severity Index: A Retro: Analysis of 'High Risk' Ped Pts. Undergoing Spinal Fusion

Mark Erickson, MD ​The Development/Implemenation of the Aristotle Spine Severity Index: A Retro: Analysis of 'High Risk' Ped Pts. Undergoing Spinal Fusion
Vertical Expandable Prosthetic Titanium Rib (VEPTR)

Mark Erickson, MD ​Vertical Expandable Prosthetic Titanium Rib (VEPTR)
Prospective Pediatric Kyphosis Study​

Mark Erickson, MD ​Prosepective Pediatric Kyphosis Study
The Use of Barbed Sutures During Spinal Fusion Surgery: A Cost Analysis (Quill)

Mark Erickson, MD ​The Use of Barbed Sutures During Spinal Fusion Surgery: A Cost Analysis (Quill)
​Are routine spine radiographs needed following surgical treatment of adolescent idiopathic scoliosis?

Sumeet Garg, MD​ ​Are routine spine radiographs needed following surgical treatment of adolescent idiopathic scoliosis?
Assessment of Clinical Deformity in Adolescent Idiopathic Scoliosis: Clinical Image Capture vs Radiograph

Sumeet Garg, MD​​ ​Assessment of Clinical Deformity in Adolescent Idiopathic Scoliosis: Clinical Image Capture vs Radiograph
Complication Rates Following Bone Morphogenetic Protein (BMP) Use in Children a Multicenter Study

Sumeet Garg, MD​​ ​Complication Rates Following Bone Morphogenetic Protein (BMP) Use in Children a Multicenter Study
Fate of the Hip After Spinal Fusion in Cerebral Palsy​

Sumeet Garg, MD​​ ​Fate of the Hip After Spinal Fusion in Cerebral Palsy
​The Chest Wall and Spine Deformity Registry

Sumeet Garg, MD​​ ​The Chest Wall and Spine Deformity Registry
Management and Bacteriology of Late Post-Spinal Fusion Infectino in Adolescents

Sumeet Garg, MD​​ ​Management and Bacteriology of Late Post-Spinal Fusion Infectino in Adolescents
Predicting Failure of Iliac Fixation in Neuromusuclar Spine Deformity

Sumeet Garg, MD​​ ​Predicting Failure of Iliac Fixation in Neuromusuclar Spine Deformity
The Utility of Radiographic Films in NM Patients​

Sumeet Garg, MD​​ ​The Utility of Radiographic Films in NM Patients
​VEPTR Implantation to Treat Children with Early Onset Scoliosis without Rib Abnormalities A Prospective Multicenter Study

Sumeet Garg, MD​​ ​VEPTR Implantation to Treat Children with Early Onset Scoliosis without Rib Abnormalities A Prospective Multicenter Study
Wound Complications of VEPTR Incisions

Sumeet Garg, MD​​ ​Wound Complications of VEPTR Incisions
Incidence of DVT and Pulmonary Embolism in the Pediatric Surgical and Trauma Patient

Gaia Georgopoulos, MD ​Incidence of DVT and Pulmonary Embolism in the Pediatric Surgical and Trauma Patient
​Non-Operative Management of Pediatric Medial Epicondyle Fractures: Predictors of Poor Results

Gaia Georgopoulos, MD ​Non-Operative Management of Pediatric Medial Epicondyle Fractures: Predictors of Poor Results
Supracondylar Fracture Treatment Patterns At TCH​ Gaia Georgopoulos, MD ​Supracondylar Fracture Treatment Patterns At TCH​

​Fassier Duval Rods for Tumors

Travis Heare, MD ​Fassier Duval Rods for Tumors
Amputee Database Travis Heare, MD​ ​Health Related Quality of Life and Surgical Outcomes of Patients Attending Amputee and Deformity Clinic.

Approaches For Treatment Of Langerhan's Cell Histiocytosis​ Travis Heare, MD​​​ ​Approaches For Treatment Of Langerhan's Cell Histiocytosis​.