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J Mark Petrash, PhD

Professor, Vice Chair of Research, Department of Ophthalmology

The following data are linked to original publications.



    1. Ruiz FX, Moro A, Gallego O, Ardevol A, Rovira C, Petrash JM, et al. Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde. Chem Biol Interact. 2011.
    2. Li G, Lee CA, Patel M, Petrash JM, Benetz BA, Tang J, Kern TS: Diabetes-induced impairment in contrast sensitivity and visual acuity in mice: contributions of p38, RAGE, and aldose reductase (submitted)
    3. Salabei JK, Li X-P, Petrash JM, Bhatnagar A, Barski OA:Functional expression of novel human and murine AKR1B genes. (in press), 2011
    4. Zablocki GJ, Ruzycki PA, Overbeek MA, Palla S, Reddy GB, Petrash JM: Aldose reductase-mediated induction of epithelial-to-mesenchymal transition (EMT) in lens. (in press), 2011
    5. Srivastava SK, Yadav UCS, Aramati RBM, Saxena A, Tammali R, Ansari N, Bhatnagar A, Petrash JM, Srivastava S, Ramana KV:  Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders. (in press), 2011.
    6. Hegde KR, Kowluru RA, Mohr S, Nagaraj RH, Petrash JM: New horizons in research on diabetic complications of the eye: special emphasis on diabetic cataracts and retinopathy. J Ophthal 2010:979040.
    7. Srinivas P, Narahari A, Petrash JM, Swamy MJ, Reddy GB. Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: Stability, aggregation, and modifications. IUBMB Life. 2010:693-702.
    8. Huang SP, Palla S, Ruzycki P, Varma A, Harter T, Reddy GB, Petrash JM (2010): Aldo-keto reductases in the eye. J Ophthal 2010:521204, 2010.
    9. Kahook MY, Liu L, Ruzycki P, Mandava N, Carpenter JF, Petrash JM, Ammar DA (2009) High molecular weight adducts in repackaged Bevacizumab. Retina 30:887-892, 2009.
    10. Muthenna P, Suryanarayana P, Gunda SK, Petrash JM, Reddy GB: Inhibition of aldose reductase by dietary antioxidant curcumin: Mechanism of inhibition, specificity and significance. FEBS Lett 583:3637-3642, 2009.
    11. Srivastava S, Vladykovskaya E, Barski OA, Spite M, Kaiserova K, Petrash JM, Chung SS, Hunt G, Dawn B, Bhatnagar A: Aldose Reductase Protects Against Early Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice. Circ Res 105:793-802, 2009.
    12. Bhagyalaxmi SG, Srivivas PNBS, Barton K, Kumar KR, Vidyvathi M, Petrash JM, Reddy GB, Padma M: A novel mutation (F71L) in A-crystallin associated with age-related cataract results in defective chaperone-like function despite unaltered structure. Biochim Biophys Acta 1792:974-981, 2009.
    13. Shi Y, Barton K, de Maria A, Petrash JM, Shiels A, Bassnett S: The stratified syncytium of the vertebrate lens. J Cell Sci 122:1607-1615, 2009.
    14. Barton KA, Hsu C-D, Petrash JM: Interactions between small heat shock protein alpha crystallin and galectin-related inter-fiber protein (GRIFIN) in the ocular lens. Biochemistry 48:3956-3966, 2009.
    15. Tammali, R, Reddy ABM, Ramana KV, Petrash JM, Srivastava SK: Aldose reductase deficiency in mice prevents axoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis 30:799-807, 2009.
    16. Saraswat M, Muthenna P, Suryanarayana P, Petrash JM, Reddy GB: Dietary sources of aldose reductase inhibitors: Prospects for alleviating diabetic complications. Asia Pac J Clin Nutr 17,558-565, 2008.
    17. Marchitti SA, Bateman B, Petrash JM, Vasiliou V: Mouse models of the cornea and lens—Understanding ocular disease. In Animal Models of Eye Research (Tsonis PA, ed); Elsevier, 2008.
    18. Reddy GB, Satyanarayana A, Balakrishna N, Ayyagari R, Padma M, Viswanath K, Petrash JM: Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy. Molec Vis 14:593-601, 2008.
    19. Chang Q and Petrash JM: Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae. Biochem Biophys Acta (Molec Cell Res) 1783:237-245, 2008.
    20. Suryanarayana P, Saraswat M, Petrash JM, Reddy GB: Emblica officinalis and its Enriched Tannoids Delay Streptozotocin-Induced Diabetic Cataract in Rats. Molec Vis 13:1291-1297, 2007.
    21. Spite M, Baba SP, Ahmed Y, Barski O, Nijhawan K, Petrash JM, Bhatnagar A, Srivastava S: Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes. Biochem J 405:95-105, 2007.
    22. Barton KA, Shui Y-B, Petrash JM, Beebe DC: Comment on: The Stokes-Einstein equation and the physiological effects of vitreous surgery. Acta Ophthal Scand 85:339-340, 2007.
    23. Chang Q, Griest TA, Harter TM, Petrash JM: Phenotypic rescue of aldo-keto reductase null Saccharomyces cerevisiae by human aldose reductase. Biochem Biophys Acta (Molec Cell Res) 1773:321-329, 2007.
    24. Estey T, Wenston PA, Cantore M, Carpenter JF, Petrash JM, Vasiliou V: Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1. J Biol Chem 282:4382-4392, 2007.
    25. Singh R, White MA, Ramana KV, Petrash JM, Satowich SJ, Bhatnagar A, Srivastava SK: Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins 64: 101-110, 2006, 2006.
    26. Hsu CD, Kymes S, Petrash JM: A transgenic model for human autosomal dominant cataract. Inv Ophthal Vis Sci 47:2036-2044, 2006.