I study the pathogenesis and persistence of chikungunya virus. Chikungunya virus is currently causing ongoing outbreaks in the Indian Ocean region and is spread by the bite of Aedes species mosquitos. Acute human disease is characterized by a sudden onset of fever and most notably severe and incapacitating musculoskeletal disease. While in most people these symptoms resolve in a few weeks, a significant portion of patients report ongoing symptoms for months to years after acute onset. Our lab utilizes a mouse model of disease to investigate the host and viral mechanisms that mediate this persistence.