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Immunology Research


Scott Alper, Ph.D. ​The Alper lab is  focused on understanding the regulation of the innate immune response, particularly as it relates to the basis for inflammatory diseases.
Rocky Baker, Ph.D. ​I have focused my research on understanding how islet-reactive CD4 T cells are activated in the context of T1D and investigating their contribution to the pathogenesis of autoimmune diabetes
John C. Cambier, Ph.D. ​In vivo biology and signaling in naïve and autoreactive human B cells, molecular function of autoimmunity risk alleles operative in regulatory signaling pathways in B cells, and STING function in B cells.
​Zhangguo Chen, Ph.D. ​My research interest is to elucidate the mechanisms of signaling control of class switch recombination and its application in autoimmunity.
Thomas Delong, Ph.D.
​We work on the identification of antigens that are targeted by disease triggering T cells in type 1 diabetes and other autoimmune diseases. For this we use advanced proteomic and chemical strategies in combination with T cell immunology. It is our goal to predict, prevent and reverse autoimmunity.
Rachel Friedman, Ph.D. ​We focus on understanding how T cell tolerance is maintained or broken by cellular and environmental factors at the disease site during autoimmunity, particularly in diabetes.
James Hagman, Ph.D. ​Work in our laboratory addresses the regulation of normal lymphocyte development by transcriptional and epigenetic mechanisms; oncogenes and leukemogenesis; and transcriptional control of autoimmunity.
Peter Henson, Ph.D. ​Cell biology of the mononuclear phagocyte system with relation to inflammation, innate and adaptive immunity and maintenance of, or return to, normal tissue homeostasis.
Elena Hsieh, M.D. ​Our goal is to enable a deeper understanding of normal pediatric immune development, dysregulated immune processes in children with immunodeficiency, autoimmunity, and the overlap between the two.
Hua Huang, M.D., Ph.D. ​Type 2 immunity, characterized by the production of type 2 cytokine interleukin (IL)-4, IL-5 and IL-13, is critical in immunity against parasitic infection and in causing allergic inflammation.  Our lab is interested in studying molecular regulation of type 2 effector cell differentiation and the expression of type 2 cytokine genes.
Jordan Jacobelli, Ph.D. ​The Jacobelli lab works on characterizing the molecular regulation of lymphocyte migration, cell-cell interactions, and activation during immune surveillance and in disease settings such as autoimmunity and cancer.
Ross Kedl, Ph.D. ​Most inflammation seems best suited for making more inflammation, not for giving T cells the signals they need to expand and survive.  My lab studies what innate signals are able to facilitate the transition between innate and adaptive responses and how that information can be best utilized in the making of novel vaccines that produce therapeutically effective T cell responses.
Laurel Lenz, Ph.D. ​We study mechanisms for regulation of innate immune responses with an emphasis on how interferons and natural killer cells impact myeloid cell responses.
Rebecca O'Brien, Ph.D. ​The overall goal of my lab is to investigate the role of gamma/delta T cells in immune responses and inflammation.  Using autoimmune disease models, we are investigating how some of these cells exacerbate autoimmunity by promoting inflammation, whereas others have an immunoregulatory effect.
Roberta Pelanda, Ph.D. ​The Pelanda lab studies the B cell intrinsic and extrinsic signals that guide the development, selection and activation of autoreactive and non-autoreactive B cells and of autoantibody-producing cells in both mice and humans, with the goal of understanding potential causes of immunodeficiencies and autoimmune diseases.
​Dohun Pyeon, Ph.D. ​Studying human papillomavirus (HPV)-induced immune dysregulation that results in suppression of the antitumor immune responses
David Riches, Ph.D. ​Our lab is focused on investigating the mechanism involved in the development and resolution of lung inflammation and fibrosis, especially the cross talk between macrophages and fibroblasts.
Rosemary Rochford, Ph.D. ​My lab studies the T cell tropism of the Epstein-Barr virus (EBV) Type 2 strain.  In addition, we are evaluating the development of immunity to EBV and P. falciparum malaria in an infant cohort based in western Kenya.
Jill Slansky, Ph.D. ​We are interested in how cancer and the immune system interact on many levels, but mainly focus on how CD8 T cells recognize tumor antigens in people and animals.
​Raul Torres, Ph.D. ​We have a long-standing interest in investigating the mechanisms by which B lymphocytes develop and subsequently mount antibody responses to foreign antigens and pathogens.
​Linda van Dyk, Ph.D. ​The van Dyk lab investigates molecular interactions between virus and host that impact infection and cancer. The main projects in the lab include analysis of a virus encoded cyclin with a host tumor suppressor protein and characterization of non-coding RNAs that regulate the innate immune response and chronic infection.
Jing Wang, M.D., Ph.D. Our research focuses on molecular mechanism of somatic hypermutation (SHM) and class switch recombination (CSR) in B lymphocytes and mechanisms of immune evasion in B cell lymphomas or head neck squamous carcinomas (HNSCC).
Gongyi Zhang, Ph.D. ​1) Epigenetic regulation in T and B cells; 2) Neurodegenerative diseases and Inflammation