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Host-Pathogen Interactions Research

David J. Barton, Ph.D. ​The Barton lab studies RNA viruses and host endoribonucleases. An RNA element within group C enteroviruses inhibits ribonuclease L - protecting the virus from this antiviral endoribonuclease. We use deep sequencing methods - in collaboration with the Hesselberth lab - to examine how endoribonucleases influence health and disease.
Kelly Doran, Ph.D.
My lab seeks to elucidate the mechanisms by which Group B streptococcus colonizes the vaginal tract during pregnancy and penetrates the blood-brain barrier in the newborn to cause meningitis.  We use molecular genetic approaches as well as cell based and animal models to identify bacterial virulence determinants and host factors that contribute to disease progression.
​Breck A. Duerkop, Ph.D. ​My current research focuses on intestinal bacteria and bacteriophages. We employ culture-based approaches, animal models, and computational methods to study how intestinal bacteriophages impact the interactions of bacteria with their mammalian hosts.
Alexander Horswill, Ph.D. ​Social activities of Staphylococci and host-pathogen interactions
​Marijke Keestra-Gounder, Ph.D. ​My research focusses on elucidating pathways of innate immunity in response to Salmonella Typhimurium and Citrobacter rodentium.
Laurel Lenz, Ph.D. ​We study how bacterial pathogens interact with myeloid and other innate immune cells, with an emphasis on their exploitation of interferons and natural killer cells.
Thomas E. Morrison, Ph.D. ​Immunological mechanisms that influence the clearance or persistence of arboviruses and protozoan parasites; Molecular mechanisms by which pathogens counteract host innate and adaptive immune responses
​Stefan Pukatzki, Ph.D. ​Mechanisms and consequences of microbial competition in the context of disease.​
Dohun Pyeon, Ph.D. ​Studying host factors/mechanisms that facilitate or inhibit human papillomavirus (HPV) infection and cervical and head and neck cancer development
R. Lee Reinhardt, Ph.D. ​My lab studies type-2 immunity in the context of allergic disease (asthma, allergy, atopic dermatitis) as well as the host response to neglected tropical diseases caused by parasitic helminth and leishmania infection. We also have ongoing research in models of autoinflammatory disease.
Rosemary Rochford, Ph.D. My lab does research on two human pathogens, Epstein-Barr virus (EBV) and Plasmodium falciparum and their etiologic link to Burkitt's lymphoma, the most common childhood cancer in Sub-Sahara Africa. 
Michael Schurr, Ph.D. ​The Schurr laboratory is interested in mechanisms of transcriptional regulation in bacterial pathogenesis and is focused on a Pseudomonas aeruginosa global two-component regulator, AlgZR that controls at least 155 genes. We are using transcriptional profiling, genetics, molecular biology and biochemistry to determine the genes controlled and conditions of expression used by P. aeruginosa for these regulators. 
Linda van Dyk, Ph.D. The van Dyk lab investigates molecular interactions between virus and host that impact infection and cancer. The main projects in the lab include analysis of a virus encoded cyclin with a host tumor suppressor protein and characterization of non-coding RNAs that regulate the innate immune response and chronic infection.
Andrés Vázquez-Torres, D.V.M., Ph.D. ​Our group studies innate host defenses of macrophages against intracellular bacterial and protozoan pathogens.