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Department of Microbiology, A Leader in Microbiology and Microbial Pathogenesis Research and Training.

Immunology and Microbiology
 

Jerome Schaack, Ph.D.

Associate Professor of Immunology & Microbiology



12800 E 19th Ave. RC-1 N 9124
Mail Stop 8333, Aurora, CO 80045
Phone: (303) 724-4220
E-mail: jerry.schaack@ucdenver.edu

Jerry Schaack, Ph.D., earned his doctoral degree from Yale University in 1983. He completed 5 years of postdoctoral research training at Yale University (1983-84) and Princeton University (1984-88).

Dr. Schaack joined the faculty of the University of Colorado School of Medicine Department of Microbiology in 1988.

My laboratory is primarily interested in the construction and analysis of adenovirus vectors for gene therapy. Adenovirus type 5 (Ad5) offers great promise as a gene therapy vector, but is limited by the strong inflammatory response that is elicited upon introduction of large amounts of the vector to transduce tissues in vivo. The inflammatory response appears to be due, at least in parts, to: 1. the introduction of the very powerful enhancer present in the CMV major immediate early promoter (the CMV promoter) used in most adenovirus vectors; 2. the deletion of the E1 genes, some of whose protein products act to inhibit inflammatory responses induced by the vector; 3. expression of the adenovirus terminal protein: deletion of this genes leads to reduced inflammation. In addition, introduction of mini chromosomal insulator sequences either upstream or downstream of the CMV promoter significantly reduces the inflammatory response and prolongs expression of the transgene.

Dr. Schaack has served on the editorial board of the Journal of Virology and the Frontiers of Bioscience.