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Funded Research Projects

by Principal Investigator


DEM faculty has been successful at obtaining internal and external funding support for a variety of research projects. Funded grants are listed below by Principal Investigator. 

 Faculty Name

Prediction of Acute Mountain Sickness Using a Blood-Based Test

Funding Agency: Department of Defense (DMDRP)

Fundinbg Period: January 2011 - November 2014

Aim:
The design of an easy-to-use, cost-effective test that accurately predicts whether or not someone is likely to develop acute mountain sickness (AMS) when they travel to high altitudes.

AltitudeOmics: The Basic Biology of Human Acclimatization To High Altitude

Funding Agency: Department of Defense (DMDRP)

Funding Period:
January 2011 - June 2014

Aim:
The advancement of high-altitude medical research by discovering the basic molecular mechanisms of acclimatization that protect soldiers from high-altitude illness.

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 Betz, Marian

Physician Screening of Older Drivers: Decision Rules for Geriatric Injury Prevention

Funding Agency: National Institutes of Health (NIH): National Institute on Aging (NIA)

Supplemental Funding from: American Foundation on Aging Research (AFAR)

Funding Period: August 15th 2013- May 31st 2018

Aim:  The application of the model of a clinical decision rule to a public health intervention, through tiered assessment of brief older driver screening in ambulatory care settings followed by referral for more comprehensive testing.

 

Emergency Department Suicide Screening and Intervention Trial (EDSSIT)

Funding Agency: University of Massachusetts via National Institutes of Health (NIH)

Funding Period: September 30th 2009- May 31st 2014

Aim:  The test of the feasibility of a standard screening instrument for depression and suicidal ideation in an emergency department and estimating the frequency of suicidal ideation in individuals presenting to the ED for problems other than mental health.

 

Pre-planning for developing a long-term multi-site prospective cohort study to better understand senior drivers

Funding Agency: Columbia University via AAA Foundation    

Funding Period: October 1st 2013-current

Aim: The AAAFTS Senior Driver Cohort Study project is designed to generate empirical evidence for understanding the dynamics, mechanisms, determinants, and consequences of mobility in senior drivers and for developing effective interventions to ensure safe mobility for older people.  With a prospective cohort design, the AAAFTS Senior Driver Cohort Study will involve enrolling a sample of at least 3,000 active drivers from five states located across the U.S. and following them for a minimum of five years.

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 Capp, Roberta

Patient Navigation Programs to Improve Care for Medicaid-Enrolled Frequent ED Users 

Funding Agency:  Colorado Clinical and Translational Sciences Institute KL2

Funding Period: December 1st 2013-November 30th 2015

Aim:  The aim of this KL2 project is to gather of information from emergency department patients, providers, and navigators on factors associated with a successful patient navigation outcome (i.e., reducing the number of ED visits) and identifying subpopulations of Medicaid-enrolled frequent ED users who benefit from patient navigation services.

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 Ginde, Adit

Vitamin D and Immunosenescence in Older Long-Term Care Residents

Funding Agency: National Institutes of Health (NIH): National Institute on Aging (NIA) 

Supplemental Funding from: American Foundation on Aging Research (AFAR)

Funding Period: September 15th 2011- May 31st 2014

Aim:  The research goals of this K23 Award are to evaluate the role of vitamin D supplementation in 1) prevention of acute respiratory infection and 2) immune responses to influenza and varicella zoster virus (shingles) vaccine in older long-term care residents.

 

Prevention and Early Treatment of Acute Lung Injury Network:  Colorado PETAL Clinical Center

Funding Agency: National Institutes of Health (NIH): National Heart, Lung, and Blood Institute (NHLBI)

Funding Period: June 14th 2014- April 30th 2021

Aim:  The goal of this project is to participate in the selection and conduct of clinical trials for the early treatment of acute lung injury and prevention in high-risk populations such as those with severe sepsis. This clinical center includes two academic and four community hospitals in the greater Denver area.

3

 Hoppe, Jason

The Use of Prescription Drug Monitoring Programs and Geographic Information Systems to Identify Communities at Risk of Prescription Opioid Overdose Fatalities

Funding Agency: Emergency Medicine Foundation (EMF)

Funding Period: July 1st 2013- June 30th 2014

Aim:  The purpose of this research is to use death records, Colorado’s Prescription Drug Monitoring Program, and geographic information systems (GIS) to identify communities at risk of prescription opioid overdose.

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 Monte, Andrew

Genotype-Phenotype Discordance in Polypharmacy Aging Patients

Funding Agency: Department of Emergency Medicine Pilot Grant

Funding Period: March 1st 2014- February 28th 2015

Aim:  The goal of this research projects is to Utilize genotyping and phenotyping of the drug-metabolizing enzyme cytochrome 2D6 (CYP2D6) to improve drug therapy in

polypharmacy patients.


An Integrated Approach to Personalized Medicine

Funding Agency: School of Medicine, Geriatrics

Funding Period: July 1st 2013-June 30th, 2015

Aim:  This research project integrates clinical, genomic, cytochrome metabolism phenotype, and metabolomic factors to develop a model that predicts systolic blood pressure decline due to metoprolol.

  

Genotype-Phenotype Discordance in Polypharmacy Aging Patients

Funding Agency: Department of Emergency Medicine, University of Colorado Denver

Funding Period: March 1st 2014- February 28th 2015

Aim: The utilization genotyping and phenotyping of the drug-metabolizing enzyme cytochrome 2D6 (CYP2D6) to improve drug therapy in polypharmacy patients.

​​

7

 Mould-Millman, Nee-Kofi

Demonstrating the Effectiveness of an African Emergency First Aid Responder System

Funding Agency: Emergency Medicine Foundation (EMF)

Funding Period: July 1st 2014- June 30th 2015

Aim:  The overarching objective of this study is to provide initial evidence that a community-based Emergency First Aid Responder (EFAR) program in sub-Sahara Africa (SSA) enhances the effectiveness and outcomes of the local emergency care system.

10

 Perman, Sarah

Efficacy and Utility of Continuous Electroencephalography in Patients Surviving Cardiac Arrest

Funding Agency: University of Colorado Hospital

Funding Period: August 1st 2013-August 1st 2014

Aim: The use of Lean management strategies to optimize the use of continuous electroencephalography (cEEG) technology in the post-cardiac arrest setting

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 Roach, Robert

Prediction of Acute Mountain Sickness Using a Blood-Based Test

Funding Agency: Department of Defense (DMDRP)

Funding Period: January 2011 - December 2015

Aim: The design of an easy-to-use, cost-effective test that accurately predicts whether or not someone is likely to develop acute mountain sickness (AMS) when they travel to high altitudes.

 

AltitudeOmics: The Basic Biology of Human Acclimatization To High Altitude

Funding Agency: Department of Defense (DMDRP)

Funding Period: January 2011 - July 2014

Aim: The advancement of high-altitude medical research by discovering the basic molecular mechanisms of acclimatization that protect soldiers from high-altitude illness.

 

Rapid Acclimatization to Hypoxia at Altitude

Funding Agency: DARPA --- PI: Irwin, D, Co-PI: Roach, R.

Funding Period: December 2012 - December 2015

Aim: The advancement of high-altitude medical research by discovering novel preventive measures for acute mountain sickness.

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 Sande, Margaret

Integration of an Audience Response System into Simulation-Based Training:  An Educational Technology Enhancement

Funding Agency: Society for Academic Emergency Medicine (SAEM)

Funding Period: December 1st 2014- November 30th 2016

Aim: The completion of a mixed-methods study to evaluate a novel technique for simulation observer engagement, publication and dissemination of results within the simulation, emergency medicine, and graduate medical education communities

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 Wiler, Jennifer

Bridges to Care

Funding Agency: Metro Community Provider Network (MCPN)

Funding Period:  July 1st 2013- June 30th 2015

Aim: The identification of high frequency utilizers of the emergency department and connect them to intensive community services and establishing them in medical homes that coordinate their care to minimize costs and return visits to the emergency department.​ 

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