Department of Dermatology
Regenerative Medicine and Stem Cell Biology Program
M.S. - Free University of Amsterdam, The Netherlands
Ph.D. - Baylor College of Medicine, Houston, TX
Postdoctoral Fellowship - Baylor College of Medicine, Houston, TX
Research Interests: Epidermal morphogenesis and differentiation; Inherited skin disorders
Overview of Ongoing Research:
My research is aimed at identifying the signaling pathways that control epidermal development and differentiation. A key regulator of epidermal development is p63, a transcription factor that is expressed as six different isoforms. Mice lacking all p63 isoforms do not develop an epidermis or skin appendages, such as hair follicles and mammary glands. Using genetically engineered mice, my laboratory studies the role of p63 isoforms during embryonic development and postnatal differentiation of the skin. In addition, p63 is mutated in a subset of ectodermal dysplasias, inherited disorders that are characterized by abnormalities of the skin and skin appendages. One of our other research objectives is to use mouse models to identify the pathogenic mechanisms that underlie skin fragility in patients with these disorders.
Recent Selected Publications:
Koster, M.I., Kim, S., Mills, A.A., DeMayo, F.J., and Roop, D.R. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 18(2):126-31, 2004.
Koster, M.I., Kim, S., Huang., J., Williams, T., and Roop, D.R. TAp63a induces AP-2g as an early event in epidermal morphogenesis. Dev Biol. 289(1): 253-261, 2006.
Nguyen, B.C., Lefort, K., Mandinova, A., Antonini, D., Devgan, V., Della Gatta, G., Koster, M.I., Zhang, Z., Wang, J., Tommasi di Vignano, A., Kitajewski, J., Chiorino, G., Roop D.R., Missero, C., and Dotto, G.P. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev. 20(8):1028-42, 2006.
Koster, M.I., Lu, S.L., Wang, X.J., and Roop, D.R. Reactivation of developmentally expressed p63 isoforms accelerates tumor development and progression. Cancer Res. 66(8):3981-6, 2006.
Keyes, W.M., Vogel, H., Koster, M.I., Guo, X., Qi, Y., Petherbridge, K.M., Roop, D.R., Bradley, A., and Mills, A.A. p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A. 103(22):8435-40, 2006.
Koster, M.I., Dai, D., Marinari, B., Sano, Y., Costanzo, A., Karin, M., and Roop, D.R. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci USA, 104(9):3255-60, 2007.
Koster, M.I., Dai, D., and Roop, D.R. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle 6(3):269-273, 2007.
Koster, M.I. and Roop, D.R. Mechanisms regulating epithelial stratification. Ann Rev Cell Dev Biol., in press.