The research mission of our faculty is to elucidate the molecular and cellular basis of diseases affecting the skin and to apply this new knowledge to prevention, diagnosis, and cure of these diseases. Research activities include molecular biology and immunology of the skin, epidemiology, genetic determinants of skin diseases including melanoma and other skin cancers, and development of approaches to gene therapy in the skin.
scope of skin disease related research at the University of Colorado is
embodied in the University of Colorado Anschutz Medical Center
Diseases Research Center (UCAMC-SDRC). This
NIAMS-funded center focuses on organizing and supporting research to better
understand the molecular basis of human autoimmune, inflammatory, developmental, metabolic,
and genetic skin diseases. The broad goal of this SDRC is to help member investigators develop models of human skin
diseases as research platforms to
molecular mechanisms of disease. This provides us with the
opportunity to develop innovative molecular approaches to correct disease processes and explore new treatment
approaches. This center includes 56 investigators, 22 from within the Department of Dermatology and 34 from other UCAMC Departments or outside
collaborators. The research interests of these investigators are broad: inflammation and immunity; epithelial biology; melanocyte biology; regenerative
medicine and stem cell biology; molecular,
cellular, and developmental biology; biochemistry; pharmacology; microbiology
and virology; genetics and genomics; tissue repair; cutaneous
carcinogenesis; and clinical research.
This is a rich platform for interdisciplinary discovery in basic and translational research.
This center is built on
strong foundation of three collaborative research teams within the CU Anschutz Medical Campus, all
headed by scientists with an established record
NIAMS-funded research: The Department of Dermatology (Dr. David Norris, Chairman), the Center for Regenerative Medicine and Stem Cell Biology
(Dr. Dennis Roop,
Director) and the Human Medical Genetics Program (Dr. Richard Spritz,
Director). There are also strong collaborations with
other centers on the AMC, especially the NCI-funded University of Colorado
Comprehensive Cancer Center.