Associate Professor of Dermatology
University of Colorado School of Medicine
Denver Veterans Affairs Medical Center
Dr. Qinghong Zang earned her Ph.D. in
physiological chemistry from the University of Wisconsin, Madison in 1997.
Prior to that, she received a Bachelor of Science in 1991 from the University
of Science & Technology of China. In addition, she has accumulated more
than three years of post-doctoral education at the Vollum Institute in Oregon.
As a teacher, she has served as a lecturer in Cancer Biology and a Mentor for a
number of PhD students. Presently, she serves as an Assistant Professor of Dermatology
and Pathology at the University of Colorado.
Qinghong Zhang’s research focuses on understanding
the dynamic changes of the transcriptional network in skin. Transcriptional
regulation governs a broad spectrum of cellular activities: cell proliferation,
differentiation, migration, apoptosis, and metabolism. She and her team are
interested in elucidating the molecular mechanisms underlying transcriptional
regulation in response to physiological and pathological signals. Particularly,
their research over the past decade has focused on CtBP, a transcriptional
co-repressor, and has uncovered a unique function of this protein as a
redox-sensor in transcription control. This function allows cells to couple the
metabolic status with gene expression in skin biology and cancer development.
Based on this research, therapeutics for skin diseases and wound healing
are in development. They have identified a biologic agent capable of topical
application for the treatment and/or prevention of psoriasis in a mouse model. The
agent’s use in other applications is currently being evaluated.