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University of Cologne

Collaborative Research Center (CRC 829)


The University of Cologne, DFG-funded Collaborative Research Center (CRC 829) "Molecular Mechanisms Regulating Skin Homeostasis” at the  (UoC) aims to understand how the different cellular and molecular components of the skin communicate to maintain skin homeostasis and to dissect the molecular basis by which this balance is disturbed thereby leading to skin diseases. Examples are chronic inflammatory diseases, atopic dermatitis, allergic diseases, barrier defect related diseases, and disturbed wound healing entities. The UoC-CRC 829 is employing genetic animal models, with an emphasis on transgenic mice but also including Zebrafish and Drosophila, to systematically unravel the molecular basis of these complex interactions in the skin. This will allow the identification of new therapeutic targets that can then be used to specifically interfere with defined steps leading to skin diseases. The CRC includes several core units that provide expertise in skin histology, immunohistochemistry, ultrastructural analysis as well as primary skin cell culture. In addition, they provide the consortium with a human skin disease tissue bank.

 

Collaborators 

Carien M. Ni​essen Regulation of epidermal morphogenesis and epidermal barrier function by intercellular junctions
Manuel Koch

Functional analysis of transmembrane collagens in skin

Catherin Niemann Molecular and cellular mechanisms of hedgehog signalling in skin homeostasis
Manolis Pasparakis​ Epithelial TNFR1 signalling in skin homeostasis and inflammation
J.Brüning /
C.​​Niessen 
Role of ​the insulin/IGF-1-regulated forkhead transcription factor (FOXO)-1 in the control of skin orphogenesis, barrier function and development of diabetes  associated skin complicatications
T. Benzing ​/
C. Reinhardt
Phosphorylation-dependent regulation of AATF controls p53-dependent apoptosis in the UV-induced DNA damage response of the skin
Björn Schumacher UV-induced DNA damage in Photoaging and skin Homeostasis​
Nils-Göran Larsson Mitochondrial dysfunction in skin ageing
M.Hammerschmidt Genetic analysis of skin development and wound healing in zebrafish​
Sandra Iden

Mammalian polarity proteins in skin homeostasis  and disease​

Sara A. Wickström Regulation of epidermal stratification and homeostasis through contractility and density sensing
Roswitha Nischt Role of basement membrane proteins in skin morphogenesis and homeostasis
R.Wagener /
M.Paulsson
Structure and function of collagen VI containing suprastructures in the dermis
Beate Eckes /
T.Krieg
Role of collagen-binding integrin receptors for cellular communication and homeostasis in the skin
Cornelia Mauch Role of MMP-14 (MT1-MMP) in skin fibrosis and tissue repair
Sabine Eming Functions of the inflammatory response in tissue repair
Ingo Haase  Regulation of skin inflammation by epidermal keratinocytes​
U. Baumann / F. Zaucke Structure-function relationships of Hsp47/SerpinH1 and its role in skin fibrosis
Gerhard Sengle​ Extracellular fibrillin microfibrils as multifunctional scaffolds integrating growth factor signalling in the skin
Mario Fabri Vitamin D regulation of the skin innate immune response