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CHaIR Publications

[2013][2012] [2011] [2010] [2009] [2008]


Chen JF, Eltzschig HK, Fredholm BB.
Adenosine receptors as drug targets - what are the challenges?
Nat Rev Drug Discov. 2013 Apr;12(4):265-86. doi: 10.1038/nrd3955. PMID: 23321985

Eltzschig HK.
Targeting Purinergic Signaling for Perioperative Organ Protection.
Anesthesiology. 2013 Jan 28. [Epub ahead of print] PMID:23360900

Eltzschig HK.
Extracellular adenosine signaling in molecular medicine.
J Mol Med (Berl). 2013 Feb;91(2):141-6. doi: 10.1007/s00109-013-0999-z. PMID:23338058

Collins CB, Aherne CM, Yeckes A, Pound K, Eltzschig HK, Jedlicka P, de Zoeten EF.
Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function.
Mucosal Immunol. 2013 Jan 16. doi: 10.1038/mi.2012.134. [Epub ahead of print] PMID:23321985


Poth JM, Brodsky K, Ehrentraut H, Grenz A, Eltzschig HK.
Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease.
J Mol Med (Berl). 2013 Feb;91(2):183-93. doi: 10.1007/s00109-012-0988-7. Epub 2012 Dec 21.PMID:23263788 [PubMed - in process]

Eltzschig HK, Sitkovsky MV, Robson SC.
Purinergic Signaling During Inflammation.
N Engl J Med. 2012 Dec 13;367(24):2322-33. doi: 10.1056/NEJMra1205750. Review. No abstract available. PMID:23234515 [PubMed - indexed for MEDLINE]
[Full text PDF]

Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK.
Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury.
Mucosal Immunol. 2012 Nov 28. doi: 10.1038/mi.2012.114. [Epub ahead of print] PMID:23187315

Masterson JC, McNamee EN, Hosford L, Capocelli KE, Ruybal J, Fillon SA, Doyle AD, Eltzschig HK, Rustgi AK, Protheroe CA, Lee NA, Lee JJ, Furuta GT.
Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis.
Gut. 2012 Nov 17. [Epub ahead of print] PMID:23161496

Grenz A, Kim JH, Bauerle JD, Tak E, Eltzschig HK, Clambey ET.
Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release.
J Immunol. 2012 Nov 1;189(9):4566-73. doi: 10.4049/jimmunol.1201651. Epub 2012 Oct 1.PMID:23028059

Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK.
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2784-93. doi: 10.1073/pnas.1202366109. Epub 2012 Sep 17.PMID:22988108

Zimmerman M, Tak E, Kaplan M, Mandell MS, Eltzschig HK, Grenz A.
Use of a hanging-weight system for liver ischemia in mice.
J Vis Exp. 2012 Aug 7;(66):e2550. doi: 10.3791/2550.PMID:22895458

Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP, Eltzschig HK.
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.
Nat Med. 2012 Apr 15. doi: 10.1038/nm.2728.

Karmouty-Quintana H, Zhong H, Acero L, Weng T, Melicoff E, West JD, Hemnes A, Grenz A, Eltzschig HK, Blackwell TS, Xia Y, Johnston RA, Zeng D, Belardinelli L, Blackburn MR.
The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease.
FASEB J. 2012 Mar 13.

Ehrentraut H, Westrich JA, Eltzschig HK, Clambey ET.
Adora2b Adenosine Receptor Engagement Enhances Regulatory T Cell Abundance during Endotoxin-Induced Pulmonary Inflammation.
PLoS One. 2012;7(2):e32416. Epub 2012 Feb 28.
[Abstract] [Full text PDF]

Grenz A, Clambey E, Eltzschig HK.
Hypoxia signaling during intestinal ischemia and inflammation.
Curr Opin Crit Care. 2012 Feb 8.

Nowak-Machen M, Rawn JD, Shekar PS, Mitani A, Tuli S, Bingold TM, Lawlor G, Eltzschig HK, Shernan SK, Rosenberger P.
Descending aortic calcification increases renal dysfunction and in-hospital mortality in cardiac surgery patients with intraaortic balloon pump counterpulsation placed perioperatively: a case control study.
Crit Care. 2012 Jan 25;16(1):R17.
[Abstract] [Full text PDF]

Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK.
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.
J Clin Invest. 2012 Feb 1;122(2):693-710. doi: 10.1172/JCI60214.
[Abstract] [Full text PDF]


Tapper E, Schmelzle M, Eltzschig HK, Robson SC.
Erratum to: Role of CD73 and extracellular adenosine in disease : Presented by Maria P. Abbracchio.
Purinergic Signal. 2011 Dec 20.
[Full Text]

Riegel AK, Busch R, Segal S, Fox JA, Eltzschig HK, Shernan SK.
Evaluation of transmitral pressure gradients in the intraoperative echocardiographic diagnosis of mitral stenosis after mitral valve repair.
PLoS One. 2011;6(11):e26559. Epub 2011 Nov 8.
[Abstract] [Full text PDF]

Eltzschig HK, Eckle T.
Ischemia and reperfusion--from mechanism to translation.
Nat Med. 2011 Nov 7;17(11):1391-401. doi: 10.1038/nm.2507. Review.

Collins CB, Aherne CM, McNamee EN, Lebsack MD, Eltzschig HK, Jedlicka P, Rivera-Nieves J.
Flt3 ligand expands CD103+ dendritic cells and FoxP3+ T regulatory cells, and attenuates Crohn's-like murine ileitis.
Gut. 2011 Nov 7.

Colgan SP, Eltzschig HK.
Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery.
Annu Rev Physiol. 2012 Mar 17;74:153-75. Epub 2011 Nov 19.

Collins CB, Aherne CM, Kominsky D, McNamee EN, Lebsack MD, Eltzschig HK, Jedlicka P, Rivera-Nieves J.
Retinoic acid attenuates ileitis by restoring the balance between T-helper 17 and T regulatory cells.
Gastroenterology. 2011 Nov;141(5):1821-31.

Rose JB, Naydenova Z, Bang A, Ramadan A, Klawitter J, Schram K, Sweeney G, Grenz A, Eltzschig HK, Hammond J, Choi DS, Coe IR.
Absence of equilibrative nucleoside transporter 1 in ENT1 knockout mice leads to altered nucleoside levels following hypoxic challenge.
Life Sci. 2011 Oct 24;89(17-18):621-30. Epub 2011 Aug 17.

Aherne CM, Collins CB, Masterson JC, Tizzano M, Boyle TA, Westrich JA, Parnes JA, Furuta GT, Rivera-Nieves J, Eltzschig HK.
Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis.
Gut. 2011 Aug 3.

Grenz A, Hong JH, Badulak A, Ridyard D, Luebbert T, Kim JH, Eltzschig HK.
Use of a hanging-weight system for isolated renal artery occlusion.
J Vis Exp. 2011 Jul 19;(53). pii: 2549. doi: 10.3791/2549.
[Abstract] [Full text PDF] [Video]

Koeppen M, Eckle T, Eltzschig HK.
The hypoxia-inflammation link and potential drug targets.
Curr Opin Anaesthesiol. 2011 Aug;24(4):363-9. Review.

Grenz A, Dalton JH, Bauerle JD, Badulak A, Ridyard D, Gandjeva A, Aherne CM, Brodsky KS, Kim JH, Tuder RM, Eltzschig HK.
Partial netrin-1 deficiency aggravates acute kidney injury.
PLoS One. 2011;6(5):e14812. Epub 2011 May 19.
[Abstract] [Full text PDF]

Koeppen M, Eckle T, Eltzschig HK.
Pressure controlled ventilation to induce acute lung injury in mice.
J Vis Exp. 2011 May 5;(51). pii: 2525. doi: 10.3791/2525.
[Abstract] [Full text PDF] [Video]

Koeppen M, Eckle T, Eltzschig HK.
Interplay of hypoxia and A2B adenosine receptors in tissue protection.
Adv Pharmacol. 2011;61:145-86. Review.

Wen J, Grenz A, Zhang Y, Dai Y, Kellems RE, Blackburn MR, Eltzschig HK, Xia Y.
A2B adenosine receptor contributes to penile erection via PI3K/AKT signaling cascade-mediated eNOS activation.
FASEB J. 2011 Aug;25(8):2823-30. Epub 2011 May 12.

Koeppen M, Di Virgilio F, Clambey ET, Eltzschig HK.
Purinergic regulation of airway inflammation.
Subcell Biochem. 2011;55:159-93.

Eckle T, Koeppen M, Eltzschig HK.
Use of a hanging weight system for coronary artery occlusion in mice.
J Vis Exp. 2011 Apr 19;(50). pii: 2526. doi: 10.3791/2526.
[Abstract] [Full text PDF] [Video]

Eltzschig HK, Robson SC.
NT5E mutations and arterial calcifications.
N Engl J Med. 2011 Apr 21;364(16):1577-8; author reply 1579-80.
[Full Text PDF]

Hart ML, Grenz A, Gorzolla IC, Schittenhelm J, Dalton JH, Eltzschig HK.
Hypoxia-inducible factor-1a-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor.
J Immunol. 2011 Apr 1;186(7):4367-74. Epub 2011 Feb 28.

Eltzschig HK, Carmeliet P.
Hypoxia and inflammation.
N Engl J Med. 2011 Feb 17;364(7):656-65. Review.

Eckle T, Eltzschig HK.
Toll-like receptor signaling during myocardial ischemia.
Anesthesiology. 2011 Mar;114(3):490-2.
[Full text PDF]

Eltzschig HK.
Targeting Hypoxia-induced Inflammation.
Anesthesiology. 2011 Feb;114(2):239-42. No abstract available.
[Full text PDF]

Bauerle JD, Grenz A, Kim JH, Lee HT, Eltzschig HK.
Adenosine generation and signaling during acute kidney injury.
J Am Soc Nephrol. 2011 Jan;22(1):14-20. Review.

Riegel AK, Faigle M, Zug S, Rosenberger P, Robaye B, Boeynaems JM, Idzko M, Eltzschig HK.
Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation.
Blood. 2011 Feb 24;117(8):2548-55. Epub 2010 Dec 20.
[Abstract] [Full text PDF] [Supplement]

Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y.
Detrimental effects of adenosine signaling in sickle cell disease.
Nat Med. 2011 Jan;17(1):79-86. Epub 2010 Dec 19.

Grenz A, Homann D, Eltzschig HK.
Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia.
Antioxid Redox Signal. 2011 Oct 15;15(8):2221-34. Epub 2011 Apr 11.


Hilberath JN, Oakes DA, Shernan SK, Bulwer BE, D'Ambra MN, Eltzschig HK.
Safety of transesophageal echocardiography.
J Am Soc Echocardiogr. 2010 Nov;23(11):1115-27; quiz 1220-1. Review.

Aherne CM, Kewley EM, Eltzschig HK.
The resurgence of A2B adenosine receptor signaling. Biochim Biophys Acta. 2011 May;1808(5):1329-39. Epub 2010 May 28. Review.

Csóka B, Németh ZH, Rosenberger P, Eltzschig HK, Spolarics Z, Pacher P, Selmeczy Z, Koscsó B, Himer L, Vizi ES, Blackburn MR, Deitch EA, Haskó G.
A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation.
J Immunol. 2010 Jul 1;185(1):542-50. Epub 2010 May 26.
[Abstract] [Full text PDF]

Schingnitz U, Hartmann K, Macmanus CF, Eckle T, Zug S, Colgan SP, Eltzschig HK.
Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury.
J Immunol. 2010 May 1;184(9):5271-9. Epub 2010 Mar 26.
[Abstract] [Full text PDF]

Hart ML, Gorzolla IC, Schittenhelm J, Robson SC, Eltzschig HK.
SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning.
J Immunol. 2010 Apr 1;184(7):4017-24. Epub 2010 Mar 5.
[Abstract] [Full text PDF]

Reuter DA, Huang C, Edrich T, Shernan SK, Eltzschig HK.
Cardiac output monitoring using indicator-dilution techniques: basics, limits, and perspectives.
Anesth Analg. 2010 Mar 1;110(3):799-811. Review.
[Abstract] [Full text PDF]


Eckle T, Koeppen M, Eltzschig HK.
Role of extracellular adenosine in acute lung injury.
Physiology (Bethesda). 2009 Oct;24:298-306. Review.
[Abstract] [Full text PDF]

Eltzschig HK, Rivera-Nieves J, Colgan SP.
Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation.
Expert Opin Ther Targets. 2009 Nov;13(11):1267-77. Review.

Eltzschig HK.
Adenosine: an old drug newly discovered.
Anesthesiology. 2009 Oct;111(4):904-15. Review.
[Abstract] [Full text PDF]

Koeppen M, Eckle T, Eltzschig HK.
Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo.
PLoS One. 2009 Aug 26;4(8):e6784.
[Abstract] [Full text PDF]

Chen H, Yang D, Carroll SH, Eltzschig HK, Ravid K.
Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury.
Exp Hematol. 2009 May;37(5):533-8.

Frick JS, MacManus CF, Scully M, Glover LE, Eltzschig HK, Colgan SP.
Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis.
J Immunol. 2009 Apr 15;182(8):4957-64.

Eltzschig HK, Eckle T, Grenz A.
PHD2 mutation and congenital erythrocytosis with paraganglioma.
N Engl J Med. 2009 Mar 26;360(13):1361-2; author reply 1362.
[Full text PDF]

Hart ML, Jacobi B, Schittenhelm J, Henn M, Eltzschig HK.
Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury.
J Immunol. 2009 Apr 1;182(7):3965-8.
[Abstract] [Full text PDF]

Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, Morote-Garcia JC, Unertl K, Eltzschig HK.
Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.
Nat Immunol. 2009 Feb;10(2):195-202. Epub 2009 Jan 4.

Morote-Garcia JC, Rosenberger P, Nivillac NM, Coe IR, Eltzschig HK.
Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia.
Gastroenterology. 2009 Feb;136(2):607-18. Epub 2008 Nov 1.

Hilberath JN, Shernan SK, Segal S, Smith B, Eltzschig HK.
The feasibility of epicardial echocardiography for measuring aortic valve area by the continuity equation.
Anesth Analg. 2009 Jan;108(1):17-22.
[Abstract] [Full text PDF]


Haeberle HA, Dürrstein C, Rosenberger P, Hosakote YM, Kuhlicke J, Kempf VA, Garofalo RP, Eltzschig HK.
Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection.
PLoS One. 2008 Oct 7;3(10):e3352.
[Abstract] [Full text PDF]

Reutershan J, Vollmer I, Stark S, Wagner R, Ngamsri KC, Eltzschig HK.
Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs.
FASEB J. 2009 Feb;23(2):473-82. Epub 2008 Oct 6.
[Abstract] [Full text PDF]

Eltzschig HK, Köhler D, Eckle T, Kong T, Robson SC, Colgan SP.
Central role of Sp1-regulated CD39 in hypoxia/ischemia protection.
Blood. 2009 Jan 1;113(1):224-32. Epub 2008 Sep 23.
[Abstract] [Full text PDF]

Hart ML, Much C, Gorzolla IC, Schittenhelm J, Kloor D, Stahl GL, Eltzschig HK.
Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning.
Gastroenterology. 2008 Nov;135(5):1739-1750.e3. Epub 2008 Aug 3.

Eckle T, Grenz A, Laucher S, Eltzschig HK.
A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.
J Clin Invest. 2008 Oct;118(10):3301-15.
[Abstract] [Full text PDF]

Zheng W, Kuhlicke J, Jäckel K, Eltzschig HK, Singh A, Sjöblom M, Riederer B, Weinhold C, Seidler U, Colgan SP, Karhausen J.
Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium.
FASEB J. 2009 Jan;23(1):204-13. Epub 2008 Sep 8.
[Abstract] [Full text PDF]

Eckle T, Füllbier L, Grenz A, Eltzschig HK.
Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice.
Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L718-24. Epub 2008 Aug 15.
[Abstract] [Full text PDF]

Faigle M, Seessle J, Zug S, El Kasmi KC, Eltzschig HK.
ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia.
PLoS One. 2008 Jul 30;3(7):e2801.
[Abstract] [Full text PDF]

Eckle T, Köhler D, Lehmann R, El Kasmi K, Eltzschig HK.
Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning.
Circulation. 2008 Jul 8;118(2):166-75.
[Abstract] [Full text PDF]

Grenz A, Osswald H, Eckle T, Yang D, Zhang H, Tran ZV, Klingel K, Ravid K, Eltzschig HK.
The reno-vascular A2B adenosine receptor protects the kidney from ischemia.
PLoS Med. 2008 Jun 24;5(6):e137.
[Abstract] [Full text PDF]

Wellmann S, Bettkober M, Zelmer A, Seeger K, Faigle M, Eltzschig HK, Bührer C.
Hypoxia upregulates the histone demethylase JMJD1A via HIF-1.
Biochem Biophys Res Commun. 2008 Aug 8;372(4):892-7. Epub 2008 Jun 4.

Hart ML, Köhler D, Eckle T, Kloor D, Stahl GL, Eltzschig HK.
Direct treatment of mouse or human blood with soluble 5'-nucleotidase inhibits platelet aggregation.
Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1477-83. Epub 2008 May 29.
[Abstract] [Full text PDF]

Hart ML, Much C, Köhler D, Schittenhelm J, Gorzolla IC, Stahl GL, Eltzschig HK.
Use of a hanging-weight system for liver ischemic preconditioning in mice.
Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1431-40. Epub 2008 Apr 24.
[Abstract] [Full text PDF]

Eltzschig HK, Macmanus CF, Colgan SP.
Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface.
Trends Cardiovasc Med. 2008 Apr;18(3):103-7. Review.
[Abstract] [Full text PDF]

Nowak M, Shernan SK, Eltzschig HK, Rosenberger P.
A novel view for visualizing a left pulmonary artery thromboembolus with intraoperative transesophageal echocardiography.
J Clin Anesth. 2008 Mar;20(2):136-8.

Hart ML, Henn M, Köhler D, Kloor D, Mittelbronn M, Gorzolla IC, Stahl GL, Eltzschig HK.
Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury.
FASEB J. 2008 Aug;22(8):2784-97. Epub 2008 Mar 19.
[Abstract] [Full text PDF]

Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Autenrieth IB, Karhausen J, Neumann D, Colgan SP, Kempf VA.
Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.
Gastroenterology. 2008 Mar;134(3):756-67. Epub 2007 Dec 7.

Morote-Garcia JC, Rosenberger P, Kuhlicke J, Eltzschig HK.
HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak.
Blood. 2008 Jun 15;111(12):5571-80. Epub 2008 Feb 28.
[Abstract] [Full text PDF]

Eltzschig HK, Rosenberger P, Löffler M, Fox JA, Aranki SF, Shernan SK.
Impact of intraoperative transesophageal echocardiography on surgical decisions in 12,566 patients undergoing cardiac surgery.
Ann Thorac Surg. 2008 Mar;85(3):845-52.

Rosenberger P, Shernan SK, Löffler M, Shekar PS, Fox JA, Tuli JK, Nowak M, Eltzschig HK.
The influence of epiaortic ultrasonography on intraoperative surgical management in 6051 cardiac surgical patients.
Ann Thorac Surg. 2008 Feb;85(2):548-53.

Redel A, Jazbutyte V, Smul TM, Lange M, Eckle T, Eltzschig H, Roewer N, Kehl F.
Impact of ischemia and reperfusion times on myocardial infarct size in mice in vivo.
Exp Biol Med (Maywood). 2008 Jan;233(1):84-93.
[Abstract] [Full text PDF]