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Clinical Research Projects at CHC

CHC Projects Listed by PI's Last Name:


PI: Brooks, Melissa
Title: Preoperative vancomycin administration for surgical site prophylaxis: plasma and soft tissue concentrations in pediatric neurosurgical and orthopedic patients
Research Interests:

PI: Cohen, Mindy
Title: The use of intraoperative intrathecal Morphine versus epidural extended release Morphine for postoperative pain control in pediatric patients undergoing posterior spinal fusions
Research Interests: Pharmacogenomics, post operative pain management, opioids and adverse events

Title: Predicting perioperative opioid adverse effects and personalizing analgesia in children: A multicenter pharmacogenetic study (in collaboration with Cincinnati Children’s Hospital Medical Center as Lead Site, Study ID 2010-1353)

Title: Genetic factors influencing morphine efficacy and adverse reactions in children

PI: Faulk, Debra
Title: Multicenter prospective analysis of pediatric sedation practice: The Pediatric Sedation Research Consortium
Research Interests: Sedation, simulation, neurodevelopmental outcomes, emergence agitation/delirium

Title: Simulation-enriched, multimodality training in procedural sedation for gastroenterology staff at Children’s Hospital Colorado

PI: Friesen, Robert
Title: The effect of anesthetic agents on neurodevelopmental outcomes of neonatal congenital heart disease patients
Research Interests: Pulmonary hypertension in children with congenital heart disease

Title: Carbon monoxide screening in preanesthetic children using Masimo pulse oximetry to measure carboxyhemoglobin

Title: Pulmonary vascular effects of dexmedetomidine in children undergoing cardiac catheterization

Title: Pulmonary vascular effects of ketamine in children with pulmonary hypertension undergoing cardiac catheterization

PI: Fuhr, Peter
Title: Wake Up Safe
Research Interests: Adverse events in pediatric anesthesiology

PI: Galinkin, Jeffrey
Title: An open-label study to characterize the pharmacokinetics and safety of Oxycodone Hydrochloride q12h Controlled-Release Tablets (ORF) in postoperative pediatric patients ages 6 to 16 inclusive, who require opioid analgesia
Research Interests: Pharmacokinetics, pharmacogenomics, opioids, drug safety

Title: An Open-label, Multicenter Study of the Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Opioid Experienced Children from Ages 6 to 16 Years Old, Inclusive, with Moderate to Severe Malignant and/or Nonmalignant Pain Requiring Opioid Analgesics

Title: Collection of induced sputum for leukotrienes assay validation

Title: An open-label, non-randomized, multicenter, ascending dose by age, single- and multiple-dose evaluation of the effectiveness, safety, and tolerability of oral liquid Oxymorphone HCl Immediate-release Oral Liquid for acute postoperative pain in pediatric subjects

Title: Development of a small volume sampling technique for fentanyl pharmacokinetic, pharmacodynamics and pharmacogenetic analysis in preterm and term neonates with and without cyanotic congenital heart disease

Title: A randomized, double-blind, controlled, multi-site study of the pharmacokinetics and pharmacodynamics of methadone vs. morphine during mechanical ventilation following cardiac surgery in neonates, infants and children

Title: In vivo assessment of calcineurin inhibitor toxicity in children

Title: Pediatric optimization of the PharmaJet Needle-free Intradermal Delivery System

Title: BUP 3031 Purdue Buprenorpphine

Title: Purdue OTR3002 An open-label, extension study to assess the long-term safety of twice daily oxycodone hydrochloride controlled-release tablets in opioid experienced children who completed the OTR3001 study

PI: Notides, Thomas
Title: Preoperative gabapentin for reduction of post-tonsillectomy pain in children 5-16 years of age
Research Interests:

PI: Polaner, David
Title: Does total intravenous anesthesia with Propofol for greater than 4 hours produce occult biochemical evidence of the Propofol infusion syndrome?
Research Interests:

Title: A multicenter study of use and complications in pediatric regional anesthesia

Title: GAS study: A multi-site randomized controlled trial comparing regional and general anaesthesia for effects on neurodevelopmental outcome of apnoea in infants (NIH R01 HD061336-01A1)

Title: Clinical outcomes and pre- and post-operative airway obstruction in children undergoing adenotonsillectomy

Title: AltitudeOmics: a study of the molecular and genetic mechanisms of adaption to high altitude and hypoxia (with Rob Roach and the University of CO Altitude Research Center)

PI: Tan, Gee Mei
Title: Using simulation as a tool for teaching non-technical skills to a team
Research Interests:Simulation, healthcare provider education

Title: Assessing the effectiveness of an educational intervention teaching “difficult conversations” to pediatric residents by using standardized patient simulation scenarios

Title: Orientation of the larynx and temperature measurements while using the perilaryngeal airway (COBRAPlus) in infants and children

PI: Twite, Mark
Title: The use of somatosensory evoked potential (SSEP) and electromyography (EMG) monitoring to describe brachial plexus and femoral nerve changes during cardiac catheterization procedures in children
Research Interests:

PI: Zuk, Jeannie
Title: BIS monitor guided sedation in the pediatric cardiac intensive care unit
Research Interests: Pediatric pain assessment, instrument/survey development, quality of life, palliative care, ethics

Title: Development of an interdisciplinary moral distress tool

Title: Healthcare provider behavior and children’s perioperative distress