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Dr. Aherne Lab


Dr. Carol Aherne's Colorado Profiles page.

 

Dr. Carol Aherne

Primary Appointment: Assistant Professor, Anesthesiology

Secondary Appointment: Assistant Professor, Physiology and Biophysics

 

Education​

  • B.Sc. in Pharmacology, University College Dublin, Ireland
  • Ph.D. in Veterinary Physiology and Biochemistry, University College Dublin, Ireland
  • Postdoctoral Research Fellow, Department of Anesthesiology, University of Colorado Denver, CO, USA
  • Research Instructor, Department of Anesthesiology, University of Colorado Denver, CO, USA

Contact Information

Mailstop B112
12700 E. 19th Avenue, room P15-8470A
Aurora, Colorado 80045
Email: carol.aherne@ucdenver.edu


Training Programs

Mucosal Inflammation Program


Research Interests

My laboratory seeks to understand and target endogenous pathways that promote intestinal mucosal barrier repair in inflammatory bowel disease (IBD).


Research Description

IBD is characterized by damage to the intestinal epithelial barrier and increased permeability of this physiological barrier in patients. Using mouse models of IBD and cell based techniques for modelling intestinal inflammation and epithelial barrier breakdown we are focused on investigating endogenous epithelial-mediated repair mechanisms in IBD. We are exploring this in two ways:

  1. We have identified epithelial derived netrin-1 induction of the cell motility gene, hyaluronan mediated motility receptor (RHAMM) as a novel molecular pathway that promotes intestinal epithelial migration and repair.
  2. We have identified induction of the mucin Muc5ac as a barrier protective mechanism in IBD.


Publications

Click here for Dr. Carol Aherne's publications on NCBI

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