Dr. Carol Aherne
Primary Appointment: Assistant Professor, Anesthesiology
- B.Sc. in Pharmacology, University College Dublin, Ireland
- Ph.D. in Veterinary Physiology and Biochemistry, University College Dublin, Ireland
- Postdoctoral Research Fellow, Department of Anesthesiology, University of Colorado Denver, CO, USA
- Research Instructor, Department of Anesthesiology, University of Colorado Denver, CO, USA
12700 E. 19th Avenue, room P15-8470A
Aurora, Colorado 80045
My laboratory seeks to understand and target endogenous pathways that promote intestinal mucosal barrier repair in inflammatory bowel disease (IBD).
IBD is characterized by damage to the intestinal epithelial barrier and increased permeability of this physiological barrier in patients. Using mouse models of IBD and cell based techniques for modelling intestinal inflammation and epithelial barrier breakdown we are focused on investigating endogenous epithelial-mediated repair mechanisms in IBD. We are exploring this in two ways:
- We have identified epithelial derived netrin-1 induction of the cell motility gene, hyaluronan mediated motility receptor (RHAMM) as a novel molecular pathway that promotes intestinal epithelial migration and repair.
- We have identified induction of the mucin Muc5ac as a barrier protective mechanism in IBD.
Click here for Dr. Carol Aherne's publications on NCBI