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Research Projects


 

 CHC Research Projects

 

 Principal Investigators A-G

PI: Brooks, Melissa
Title: Preoperative vancomycin administration for surgical site prophylaxis: plasma and soft tissue concentrations in pediatric neurosurgical and orthopedic patients 
Research Interests:
 
PI: Cohen, Mindy
Title: The use of intraoperative intrathecal Morphine versus epidural extended release Morphine for postoperative pain control in pediatric patients undergoing posterior spinal fusions
Research Interests: Pharmacogenomics, post operative pain management, opioids and adverse events
 
Title: Predicting perioperative opioid adverse effects and personalizing analgesia in children: A multicenter pharmacogenetic study (in collaboration with Cincinnati Children’s Hospital Medical Center as Lead Site, Study ID 2010-1353)
 
Title: Genetic factors influencing morphine efficacy and adverse reactions in children
PI: Faulk, Debra
Title: Multicenter prospective analysis of pediatric sedation practice: The Pediatric Sedation Research Consortium
Research Interests: Sedation, simulation, neurodevelopmental outcomes, emergence agitation/delirium
Title: Simulation-enriched, multimodality training in procedural sedation for gastroenterology staff at Children’s Hospital Colorado
PI: Friesen, Robert 
Title: The effect of anesthetic agents on neurodevelopmental outcomes of neonatal congenital heart disease patients 
Research Interests: Pulmonary hypertension in children with congenital heart disease
Title: Carbon monoxide screening in preanesthetic children using Masimo pulse oximetry to measure carboxyhemoglobin
Title: Pulmonary vascular effects of dexmedetomidine in children undergoing cardiac catheterization
Title: Pulmonary vascular effects of ketamine in children with pulmonary hypertension undergoing cardiac catheterization
PI: Fuhr, Peter 
Title: Wake Up Safe 
Research Interests: Adverse events in pediatric anesthesiology
PI: Galinkin, Jeffrey 
Title: An open-label study to characterize the pharmacokinetics and safety of Oxycodone Hydrochloride q12h Controlled-Release Tablets (ORF) in postoperative pediatric patients ages 6 to 16 inclusive, who require opioid analgesia 
Research Interests: Pharmacokinetics, pharmacogenomics, opioids, drug safety
Title: An Open-label, Multicenter Study of the Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Opioid Experienced Children from Ages 6 to 16 Years Old, Inclusive, with Moderate to Severe Malignant and/or Nonmalignant Pain Requiring Opioid Analgesics
Title: Collection of induced sputum for leukotrienes assay validation
Title: An open-label, non-randomized, multicenter, ascending dose by age, single- and multiple-dose evaluation of the effectiveness, safety, and tolerability of oral liquid Oxymorphone HCl Immediate-release Oral Liquid for acute postoperative pain in pediatric subjects
Title: Development of a small volume sampling technique for fentanyl pharmacokinetic, pharmacodynamics and pharmacogenetic analysis in preterm and term neonates with and without cyanotic congenital heart disease
Title: A randomized, double-blind, controlled, multi-site study of the pharmacokinetics and pharmacodynamics of methadone vs. morphine during mechanical ventilation following cardiac surgery in neonates, infants and children
Title: In vivo assessment of calcineurin inhibitor toxicity in children
Title: Pediatric optimization of the PharmaJet Needle-free Intradermal Delivery System
Title: BUP 3031 Purdue Buprenorpphine
Title: Purdue OTR3002 An open-label, extension study to assess the long-term safety of twice daily oxycodone hydrochloride controlled-release tablets in opioid experienced children who completed the OTR3001 study
 
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 Principal Investigators H-M

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 Principal Investigators N-Z

PI: Notides, Thomas 
Title: Preoperative gabapentin for reduction of post-tonsillectomy pain in children 5-16 years of age 
Research Interests:
 
PI: Polaner, David 
Title: Does total intravenous anesthesia with Propofol for greater than 4 hours produce occult biochemical evidence of the Propofol infusion syndrome? 
Research Interests:
Title: A multicenter study of use and complications in pediatric regional anesthesia
Title: GAS study: A multi-site randomized controlled trial comparing regional and general anaesthesia for effects on neurodevelopmental outcome of apnoea in infants (NIH R01 HD061336-01A1)
Title: Clinical outcomes and pre- and post-operative airway obstruction in children undergoing adenotonsillectomy
Title: AltitudeOmics: a study of the molecular and genetic mechanisms of adaption to high altitude and hypoxia (with Rob Roach and the University of CO Altitude Research Center)
PI: Tan, Gee Mei 
Title: Using simulation as a tool for teaching non-technical skills to a team 
Research Interests:Simulation, healthcare provider education
Title: Assessing the effectiveness of an educational intervention teaching “difficult conversations” to pediatric residents by using standardized patient simulation scenarios
Title: Orientation of the larynx and temperature measurements while using the perilaryngeal airway (COBRAPlus) in infants and children
PI: Twite, Mark 
Title: The use of somatosensory evoked potential (SSEP) and electromyography (EMG) monitoring to describe brachial plexus and femoral nerve changes during cardiac catheterization procedures in children 
Research Interests:
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 UCH Research Projects

 

 Principal Investigators A-G

Title: A randomized, open label, efficacy and safety study of OCTAPLEX and Fresh Frozen Plasma (FFP) in patients under vitamin K antagonist therapy with the need for urgent surgery or invasive procedure
Description:
 
Title: Fundamental Critical Care Support
Description:
Title: Impact of prophylactic high flow nasal oxygen in post-operative thoracic surgical patients
Description:
PI: Bucklin, Brenda; Hawkins, Joy; Warrick, Christine 
Title: Maternal Cardiac Disease in Pregnancy: Maternal Anesthetic Management & Outcomes 
Description: Review maternal and neonatal outcomes during the peripartum period in pregnancies complicated by maternal cardiac disease, and any influence of anesthetic management.
Title: Neutrophil activation during mechanical ventilation 
Description: Clinical study to study the correlation between the tidal volume and biomarkers of neutrophil activation in the breath condensate and plasma.
Title: Role of heme oxygenase-1 in obesity 
Description: Pilot study to compare HO-1 expression in adipose tissue, plasma and urine of obese and lean surgical patients and its correlation with inflammatory and fat metabolism markers.
PI: Fernandez-Bustamante, Ana; Jameson, Leslie
Title: Effect of intraoperative use of reversal of neuromuscular blocking agents on clinical outcomes 
Description: Database outcomes study to explore the effect of lack of intraoperative reversal of neuromuscular blocking agents on clinical outcomes.
Title: Effect of altitude and obesity on surgical patients with sleep apnea 
Description: Outcomes study through the Multicenter Peri-Operative Group (MPOG) to analyze the effect of altitude and the Body Mass Index (BMI) distribution on surgical patients with sleep apnea, and explore the implications on perioperative clinical outcomes.
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PI: Fernandez-Bustamante, Ana; Moine, Pierre; Brainard, Jason
Title: Use of high flow nasal cannula in the perioperative period 
Description: Study to test the tolerance and clinical benefit of using humidified high flow oxygen therapy through nasal cannula in the perioperative setting. Drs. Moine and Brainard are co-investigators
Title: Investigation of the effect of nitric oxide on ischemia reperfusion injury during extended donor criteria liver transplantation 
Description: This study looks at patients undergoing liver transplantation with extended criteria donors. These donors are at higher risk for delayed graft function secondary to ischemia reperfusion injury. The hypothesis is that the administration of nitric oxide with blunt this ischemia reperfusion injury and subsequent delayed graft function.
Title: Continuous femoral nerve blockade in patients undergoing outpatient patellar graft or allograft ACL surgery 
Description: This study compares single shot peripheral nerve blockade to continuous femoral nerve blockade in patients undergoing ACL surgery. The hypothesis is that continuous femoral blockade will provide superior analgesia and less opioid mediated side effects.
PI: Fuller, Andrea 
Title: 30 year update of the obstetric anesthesia workforce survey 
Description: Every 10 years the Society of Obstetric Anesthesia and Perinatology (SOAP) sponsors a large survey of approximately 1200 hospitals across the country to look at workforce and patient care trends.
 
PI: Grenz, Almut
Title: Role of adenosine-mediated pathways in attenuating ischemia-reperfusion injury in renal and liver transplantation 
Description:  
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 Principal Investigators H-M

PI: Bucklin, Brenda; Hawkins, Joy; Warrick, Christine 
Title: Maternal Cardiac Disease in Pregnancy: Maternal Anesthetic Management & Outcomes 
Description: Review maternal and neonatal outcomes during the peripartum period in pregnancies complicated by maternal cardiac disease, and any influence of anesthetic manageme
 
PI: Hornick, Lynn 
Title: Topical Prologel for treatment of chronic back pain 
Description: Trigger point injections with ketamine for treatment of headaches and back pain Each are to evaluate effectivenss for chronic pain conditions
PI: Jameson, Leslie
Title: Effect of the Use of Neuromuscular Blockade Agents (NMBA) Reversal Drugs on Clinical Outcomes of Surgical patients
Description:
 
PI: Fernandez-Bustamante, Ana; Jameson, Leslie
Title: Effect of intraoperative use of reversal of neuromuscular blocking agents on clinical outcomes 
Description: Database outcomes study to explore the effect of lack of intraoperative reversal of neuromuscular blocking agents on clinical outcomes.
 
PI: Fernandez-Bustamante, Ana; Jameson, Leslie 
Title: Effect of altitude and obesity on surgical patients with sleep apnea 
Description: Outcomes study through the Multicenter Peri-Operative Group (MPOG) to analyze the effect of altitude and the Body Mass Index (BMI) distribution on surgical patients with sleep apnea, and explore the implications on perioperative clinical outcomes.
 
Title: Phase 2/3 Double Blind Placebo Controlled Two Part Study (Part 1 Open Label) to Assess the Safety, Efficacy and Pharmcokinetics of Single Intravenous Doses of ASP8597 (Diannexin) in DeNovo Kidney Tranpslant Recipients 
Description:
Title: Controlled Randomized Prospective Double Blind Multicenter Phase I/II Dose Escalation Study of the Safety, PK, and Clinical Activity of 15NP for Prophylaxis of Delayed Graft Function in Patients Undergoing Deceased Donor Kidney Transplantation 
Description:
Title: Reversal of Anitcoagulation Using Detergent Washed Frozen Plasma 
Description:
Title: Adult to Adult Living Donation Protocols: Donor Pain Quality Assurance NIH 051712: 3 year Study 
Description:
Title: Identification of Serum Markers of Ischemia Reperfusion Injury in Liver Transplant Patients
Description:
Title: Evaluation of the Changes in Systolic and Diastolic Function Using Transthoracic Echocardiography in Patients with Liver Disease Waiting for Transplanation
Description:
Title: Perioperative antibiotic prophylaxis in liver transplantation. Evaulation of pharmacokinetics and pharmacodynamic target attainment of cefotaxime and ampicillin-slubactam in liver transplant patients
Description:
Title: Antibiotic Prophylaxis Adherence to Guidelines and Recommendations for Total Knee Arthroplasty and Total Hip Arthroplasty Surgical Site Infections (SSI) Prevention
Description:
PI: Fernandez-Bustamante, Ana; Moine, Pierre; Brainard, Jason 
Title: Use of high flow nasal cannula in the perioperative period 
Description: Study to test the tolerance and clinical benefit of using humidified high flow oxygen therapy through nasal cannula in the perioperative setting. Drs. Moine and Brainard are co-investigators.
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 Principal Investigators N-Z

PI: Puskas, Ferenc
Title: A multicenter, open label study to evaluate the SolidAIRity Oral Indotracheal Tube and Stabilizer for safey and tolerability in subjects requiring oral intubation for airway management 
Description:
Title: Clinical Evaluation of Non-Invasive Diffuse Spectrosopic Monitoring Equipment in a Hospital Setting
Description:
Title: TBD
Description: Repiratory rate montioring in PACU setting
PI: Seres, Tamas
Title: A study into the prevalence of diastolic dysfunction in cirrhosis
Description:
PI: Serkova, Natalie 
Title: A Phase I, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of MINT1526A, Administered Intravenously as a Single Agent and in Combination with Bevacizumab to Patients with Advanced Solid Tumors 
Description: This is a Genentech-sponsored multi-center Phase I clinical trial to evaluate anti-cancer effects of a novel vascular-disruptive agent MINT1526A, alone and in combination with the FDA-approved anti-angiogenic agent bevacizumab, using novel vessel-size imaging (VSI MRI) as a pharmacodynamic end-point. Patients who qualify (liver, lung, or pelvic metastatic lesions measured as >2 cm, but <8 cm) and consent to MRI, will undergo a total of four scanning sessions: two baseline scans (one T2-w VSI MRI with iron-oxide nanoparticles and 48 hr later one T1-w DCE-MRI scan with conventional gadolinium contrast) and two on-treatment scans (Day 15 of Cycle 1). Changes in the vessel size and tumor vascularity by MRI will be correlated with patients’ RECIST reads.
 
PI: Sullivan, Breandan
Title: Clinical Evaluation of a Prototype Pulse Oximetry Board with Max-Fast on Ventilated Patients 
Description:
Title: A Retrospective review of post-operative delirium and perioperative risk factors in the SICU patient 
Description:
PI: Weitzel, Nathaen; Burger, Evalina; Patel, Vikas; Jameson, Leslie 
Title: Prospective analysis of coagulation profile testing to predict coagulopathy and related morbidity in major spine surgery: Identifying the patient at risk. 
Description:
PI: Weitzel, Nathaen; Seres, Tamas; Hansen, Kirk 
Title: Coagulation profile testing in patients undergoing cardiopulmonary bypass to predict coagulopathy and related comorbidity 
Description:
PI: Weitzel, Nathaen; Justison, George 
Title: Critical O2 Delivery Profile as a Transfusion Trigger during Cardiopulmonary Bypass 
Description:
PI: Wischmeyer, Paul
Title: A randomized trial of glutamine and antioxidant supplementation in critically ill patient.  The REDOXS Study
Description: 1250 patient, 34 center, Multi-National trial of Glutamine and Anti-Oxidants to improve survival in Critically Ill Patients.
Funding: Canadian Institutes of Health Research Large Trials Grant
Title: Efficacy and Mechanisms of Glutamine Dipeptide in the SICU
Description: Multi-center trial of glutamine dipeptide in surgical critical care patients evaluating possible mechanisms of benefit and outcome.
Funding: NIH U01 DK069322
Title: Effects of Glutamine on Heat Shock Protein Expression in Healthy Volunteers 
Description: Clinical trial of glutamine’s effect on HSP expression in cells, tissues, and serum in Healthy Volunteers.
Funding: NIH R03 DK073035  and Fresenius Kabi Inc.
Title: A randomized trial of enteral glutamine to minimize thermal injury.  The REENERGIZE Study 
Description: Multi-national 10 center,  200 patient trial to assess effect of enteral glutamine in burn injury. Precursor to planned 1200 patient multi-center trial powered on mortality.
Funding: Department of Defense (DOD) Clinical Trial Grant, American Burn Association, Canadian Institutes for Health Research
Title: A Phase IV, Multicenter, Observational Study Evaluating Hemodynamic Outcomes with BREVIBLOC PREMIXED INJECTION (Esmolol Hydrochloride) in Patients with Supraventricular Tachycardia/Atrial Fibrillation in Medical and Neurological ICU’s in the United States
Description: Multi-national 10 center,  200 patient trial to assess effect of enteral glutamine in burn injury. Precursor to planned 1200 patient multi-center trial powered on mortality.
Funding: Baxter Clinical Trial Grant
Title: Evaluation of an oral nutritional supplement containing AN 777 in older hospitalized patients (CAP study) 
Description: Clinical trial of a high protein nutrition supplement to prevent lean body loss in elderly pneumoniapatients.
Funding: Abbott Health Nutrition Institute
Title: A randomized trial of supplementalparenteral nutrition in under and over weight critically ill patients.  The TOP-UP study 
Description: NIH-funded, Multi-Center Trial of supplemental PN calories delivery to low and high BMI malnourished ICU patients to improve survival. Utilizes an IND-approved new PN formulation incorporating olive oil, high protein, and lower dextrose delivery in a safer premixed formulation. Trial is a 160 patient, 7 center pilot trial with a  2000 patient full-scale trial planned following pilot phase.
Funding: NIH R34 HL109369
Title: The Nutriate Study 
Description: A randomized double blind, placebo-controlled, active compared trial of the motilin receptor agonist GSK962040 in ICU patients.
Funding: GSK Phase 3 Clinical Trial Grant
PI: Wood, Cristina 
Title: Peripartum Cardiac Output and Stroke Volume in Healthy Pregnant Patients Undergoing Cesarean or Vaginal Delivery 
Description: We will be analyzing 30 healthy (ASA I-II),18-35 year old parturients undergoing either cesarean delivery (primary or repeat) with neuraxial anesthesia or vaginal delivery with epidural analgesia. Using NICOMTM non-invasive technology (evaluation of aortic blood flow phase shifts of propagating waves, which are detected and processed by skin sensors), we will measure cardiac output and stroke volume prior to the placement of the neuraxial anesthetic either for cesarean or vaginal delivery. We will obtain continuous data through delivery and 1 hour postpartum.
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