University of Colorado
Anschutz Medical Campus
The student must have completed one year of college.
Number of opennings:1
One major goal of
the lab is to define the role of estrogen and progesterone in the growth and
metastasis of ovarian cancer. We address the role of hormone replacement
therapy through long term in vivo modeling and in vitro molecular biology.
second major goal of the lab is to assess the interaction of TRAIL receptors
and EYA homeobox proteins in the prognosis and treatment of ovarian cancers.
routinely in use in the lab include quantitative PCR, western blotting,
fluorescent in vivo and in vitro imaging, immunohistochemistry,
immunocytochemistry, tissue culture, and microRNA analysis.
projects are examining the estrogen related changes in microRNAs in tumor
samples; delineating the role of estrogen in metastasis of ovarian cancer cells
from the abdominal cavity into lymph nodes; and defining the partner proteins
of the estrogen receptor in ovarian cancer cell lines.