University of Colorado Boulder, Department of Molecular, Cellular and Developmental Biology
Must have completed one year of college genetics and cell biology
Number of Openings: 1
We have identified a large number of basal body components in the ciliate Tetrahymena. The basal body is very similar to the centriole found in centrosomes. Tumor cells often over-produce centrioles causing defects in the mitotic spindles that contribute to genetic instability.
Molecular genetic and cell biology work with various basal body genes in Tetrahymena will help elucidate their function in the assembly mechanism that is conserved between basal bodies and centrioles.
Our research program on basal bodies and other Microtubule Organizing Centers is described at: http://mcdb.colorado.edu/labs/wineylab/