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University of Colorado Cancer Center

University of Colorado Cancer Center, A National Cancer Institute-designated Comprehensive Cancer Center
 

Enrique Torchia, PhD and Dennis Roop, PhD

Preceptors


Specialty:

Oncogenes, Cancer progression, Genomic Instability in Cancer

Location: 

University of Colorado Anschutz Medical Campus

Prerequisites: 

Two completed years of college with emphasis on biochemistry or cell biology

Number of Openings: 1-2

Objective: 

Ongoing cancer projects focus on unraveling how the oncogene Aurora Kinase A or gain-of-function (GOF) mutations in the tumor suppressor p53 promote the formation of metastatic skin carcinomas.

Description:

Students will (1) aid in the characterization of target genes of GOF p53 in genetically engineered mouse skin cancer models and in human SCC cell lines, and (2) help to determine if Aurora Kinase-A can cooperate with Ras signaling to transforms skin epithelial cells in vitro. Techniques that will be learned include qPCR, tissue culture, immunostaining and confocal microscopy. Students will also learn to organize data, interpret and discuss results according to the literature.