Category:
Cell Growth, Death and Senescence, Signaling Pathways
Specialty:
Immunology, Microbiology, Cellular & Molecular Biology
Location:
National Jewish Health, Denver, CO
Contact: (303) 398-1767; lenzl@njc.org
Prerequisites: 2 Years of college
Number of Openings: 1
Program Objective:
Characterization of microbial NFkB inhibitors.
Program Description:
NFkB family transcription factors regulate the expression of genes involved in cell activation, survival, and growth. These factors can contribute to cancer either directly or through their effects on inflammatory processes. We have identified microbial factors that interfere with NFkB-dependent gene expression. The project would use biochemical, molecular and cell biological techniques to determine how these factors inhibit NFkB signaling. The student may also work with other lab personnel to investigate the effects of these factors on survival and growth of primary and tumor cells.