Cell Growth, Death and Senescence, Signaling Pathways
Immunology, Microbiology, Cellular & Molecular Biology
National Jewish Health, Denver, CO
Must have completed two years of college
Number of Openings: 1
Non-canonical responses to type I interferons.
Type I interferons (IFNs) are cytokines that bind cell surface receptors to
regulate the expression of genes involved in cell activation, survival, and
growth. The ability of type I IFNs to trigger apoptosis in cancer cells has
been exploited with some effectiveness in therapy of human cancers.
However, the effectiveness of type I IFNs in such therapies is reduced by
their ability to exert suppressive effects on immune responses. We have begun
to dissect a novel non-canonical signal transduction pathway that mediates
immune suppressive effects of type I IFNs. A better understanding of this
pathway may reveal strategies to selectively block the immune suppressive
effects of type I IFNs and thus improve their effectiveness in cancer therapy.
The project available for students will (in collaboration with other lab
personnel) employ biochemical, molecular and cell biological techniques to
dissect specific features of this non-canonical signaling pathway.