Oncogenes and Tumor Suppressor Genes, Gene Regulation and Transcription Factors
National Jewish Health, Integrated Department of Immunology
Must have completed at least three years of college
Number of Openings: 1
determine how transcription factors and epigenetic regulators control gene
expression in normal B lymphocyte development and leukemia.
The student will assist with studies of
EBF1:PDGFRB, an oncogenic fusion protein in B cell acute lymphoblastic
leukemia. EBF1 directs progenitor cells to become B cells, while PDGFRB
is a tyrosine kinse. Unique properties of the fusion protein arrest B
cell development, while driving cell division of cancer cells.