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University of Colorado Cancer Center

University of Colorado Cancer Center, A National Cancer Institute-designated Comprehensive Cancer Center

James Hagman, PhD



Oncogenes and Tumor Suppressor Genes, Gene Regulation and Transcription Factors




National Jewish Health, Integrated Department of Immunology


Must have completed at least three years of college

Number of Openings: 1

Program Objective:

To determine how transcription factors and epigenetic regulators control gene expression in normal B lymphocyte development and leukemia.

Program Description:

The student will assist with studies of EBF1:PDGFRB, an oncogenic fusion protein in B cell acute lymphoblastic leukemia.  EBF1 directs progenitor cells to become B cells, while PDGFRB is a tyrosine kinse.  Unique properties of the fusion protein arrest B cell development, while driving cell division of cancer cells.


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