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University of Colorado Cancer Center

University of Colorado Cancer Center, A National Cancer Institute-designated Comprehensive Cancer Center
 

James Hagman, PhD

Preceptor


Category:

Oncogenes and Tumor Suppressor Genes, Gene Regulation and Transcription Factors

Specialty:

Immunology

Location:

National Jewish Health, Integrated Department of Immunology

Prerequisites:

Must have completed at least three years of college

Number of Openings: 1

Program Objective:

To determine how transcription factors and epigenetic regulators control gene expression in normal B lymphocyte development and leukemia.

Program Description:

The student will assist with studies of EBF1:PDGFRB, an oncogenic fusion protein in B cell acute lymphoblastic leukemia.  EBF1 directs progenitor cells to become B cells, while PDGFRB is a tyrosine kinse.  Unique properties of the fusion protein arrest B cell development, while driving cell division of cancer cells.