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Robert C. Doebele, MD, PhD



Lung Cancer Biology


University of Colorado Anschutz Medical Campus, Department of Medicine


Must have completed two years of college

Number of openings: 1

Program objectives:

To learn experimental techniques in basic research related to cancer biology

Program description:

Dr. Doebele’s research is focused on basic and translational research related to lung cancer.  His laboratory is developing predictive biomarkers for targeted lung cancer therapy and studying the molecular mechanisms of resistance to targeted therapy in lung cancer.  We study oncogenic gene fusions in lung cancer including ALK, ROS1, RET and NTRK1 using molecular, cellular, genetic, and translational approaches to elucidate both the sensitivity and cellularresistance to oncogene-targeted therapy. We utilize cell line and animal models of lung cancer and have derived several new cell lines from tumors harboring oncogenic fusions.  This research is facilitated by two IRB-approved protocols that support our translational research in oncogene-directed therapies in lung cancer:  (1) that directs analysis of pre- and post-targeted therapy tumor samples to study mechanisms of tumor cell resistance to targeted therapies and (2) that allows collection of clinicaldata on lung cancer patients who have undergone molecular testing. Ultimately, our goal is to advance personalized medicine through the identification andanalysis of driver oncogenes in lung cancer in order to improve the clinical outcomes of patients with this disease.