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University of Colorado Cancer Center

University of Colorado Cancer Center, A National Cancer Institute-designated Comprehensive Cancer Center
 

J. Lucas Argueso, PhD

Preceptor


Specialty:

Genetic Recombination / DNA repair / Genomics

Location:

Department of Environmental and Radiological Health Sciences
Colorado State University, Fort Collins Campus

Prerequisites:

2 years of college

Number of Openings: 1

Objective:

The broad goal of our ongoing project is to investigate the molecular mechanisms associated with structural genomic variation. Specifically, the lab studies chromosomal rearrangements that result in gene copy number variation (CNV).

Description:

Students will employ the budding yeast model system to examine DNA replication, recombination, and repair pathways that contribute to maintaining the integrity of chromosomes. They are also going to examine potential environmental exposures that may increase the incidence of chromosomal rearrangements.

Students will assist other lab members with ongoing projects and will perform CNV assays and examine the rearranged karyotypes of the resulting yeast cells, using molecular methods including microarray-based comparative genomic hybridization (array-CGH) and pulse field gel electrophoresis (PFGE).