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Center for Women’s Health Research

Center for Womens Health Research
 

Yoel Sadovsky, MD


Yoel Sadovsky, MD

Dr. Sadovsky is the Director of the Magee-Womens Research Institute, Elsie Hilliard Hillman Chair of Women’s Health Research and Professor of OBGYN, Microbiology and Molecular Genetics, and CTSI in the Department of OBGYN and Reproductive Sciences at the University of Pittsburgh School of Medicine.​

Yoel Sadovsky received his MD degree from the Hebrew University-Hadassah Medical School in Jerusalem in 1986, followed by OBGYN residency at Washington University in St. Louis and maternal-fetal medicine and postdoctoral research fellowships at the University of California, San Francisco. He then returned to Washington University as a reproductive biologist and specialist in high-risk pregnancy, where he was appointed tenured professor of OBGYN, and Cell Biology and Physiology. Dr. Sadovsky served as director of the Maternal-Fetal Medicine Fellowship at Washington University between 1997-2007, and as Director, Division of Maternal-Fetal Medicine and Ultrasound from 1999-2007. In 2007, he assumed Directorship of Magee-Womens Research Institute (MWRI) at the University of Pittsburgh, and Vice Chair (Research), Department of Obstetrics, Gynecology and Reproductive Sciences. MWRI is the hub for approximately 110 basic and translational reproductive biology researchers at the University of Pittsburgh, 70 of whom reside at the Institute’s 120,000 sq ft research building and in the adjacent Magee-Womens Hospital.​

Dr. Sadovsky’s research on feto-placental development and trophoblast function parallels his clinical expertise in maternal-fetal medicine. Using human placental cells as well as mouse models, he studies molecular pathways that govern placental development and adaptive response to stress. Primary areas of research include: (1) Placental uptake and processing of metabolic fuels, with studies that center on the uptake, storage, and trafficking of fatty acids that are critical for feto-placental development, (2) The role of microRNA in placental function, where the lab combines computationally identified sets of miRNA targets with transcriptomic analysis, as well as overexpression and silencing approaches, to define critical placental microRNA targets, (3) Placental injury and adaptation, where the lab defines hypoxic trophoblast signature pathways that govern trophoblast adaptation to injury. Dr. Sadovsky’s laboratory is funded via several NIH grants, and his investigation has resulted in the publication of 106 peer-reviewed scientific articles and 17 book chapters and invited publications, and his selection for the Society for Gynecologic Investigation’s (SGI) President’s Achievement Award in 2004.​

Dr. Sadovsky has served on several National Institute of Child Health and Human Development (NICHD) study sections, chaired the NICHD Maternal-Fetal Biology Research Study Section in 2005-06, the NICHD Genomic and Proteomic Network for Preterm Birth Research steering committee, and is currently a member of the NICHD Advisory Council and the NICHD Division of Intramural Research Review Panel. He chairs the March of Dimes Prematurity Research Initiative Advisory Committee, is a member of the March of Dimes Scientific Advisory Council and a number of other academic advisory boards. He was recently appointed Editor for the journal Placenta.​

Dr. Sadovsky has trained numerous students, residents, post-doctoral fellows and faculty. He is the Research Director of the Magee-Womens Basic and Translational Reproductive Health Training (WRHR, NIH K12) Program, and recently submitted the competitive renewal of the University’s long-standing Building Interdisciplinary Research Careers in Women’s Health (BIRCWH, NIH K12) program, and anticipates assuming directorship of this program in 2013.​