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Petter Bjornstad, MD

Dr. Bjornstad is a clinical researcher with a focus is on sex-specific metabolic and hemodynamic mechanisms underlying the development of diabetic kidney disease in type 1 and type 2 diabetes. He is the principal investigator of the Center for Women’s Health Research-funded project “Sex-related Differences in Vasopressin, Renin- Angiotensin-Aldosterone System and Intrarenal Hemodynamic Function in Adults with Longstanding Type 1 Diabetes”. The preliminary epidemiologic data from that study demonstrated that women with type 1 diabetes have higher copeptin concentrations, a marker of vasopressin activity, than non-diabetic women, a difference not observed in men with or without type 1 diabetes. Furthermore, the study demonstrated strong relationships between copeptin and diabetic kidney disease in women with type 1 diabetes. Finally, the data suggested important differences in renin-angiotensin-aldosterone system (RAAS) activity and intrarenal hemodynamic function in men and women with type 1 diabetes, the mechanisms for which remain unclear. The study tests the hypothesis that sex-specific interactions between vasopressin and RAAS may explain differences in intrarenal hemodynamic function and risk of diabetic kidney disease in men and women with type 1 diabetes.