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Kathryn Chatfield, MD, PhD

Dysregulated Cardiolipin Biosynthesis and Altered Mitochondrial Energy Production in Pediatric Idiopathic Dilated Cardiomyopathy

This research aims to understand what causes heart muscle disease, or cardiomyopathy, in children. Specifically, Dr. Chatfield is investigating idiopathic dilated cardiomyopathy (IDC), where the cause of heart failure is typically unknown but will lead to death or heart transplant in 30% of children by 1 year from the time of diagnosis.
Goals of this research are to understand how IDC is different in male and female children and how this disease in children differs from IDC in adults. Better understanding of the causes of IDC will help direct new medical and dietary therapies to improve the outlook for children diagnosed with this devastating disease.