Professor Moore has over 200 publications centering on
the effects of hypoxia on maternal and fetal health with more than 30 yrs of
NIH, NSF or other federal agency funding.
She has been a pioneer in studies using high altitude as a model for
investigating the mechanisms by which hypoxia interferes with fetal growth,
with hers being the first to focus on the effects of hypoxia on maternal
physiologic responses to pregnancy.
Working with several medical school and arts & sciences faculty at
the University of Colorado Denver, she pioneered a novel study design for
identifying the role of genetic factors by comparing the physiologic responses
of multigenerational (Andean, Tibetan) vs. shorter resident high-altitude
populations (Europeans, Han Chinese).
These studies showed that Andeans and Tibetans were protected from
hypoxia-associated fetal growth restriction relative to European or Han
("Chinese") groups and that such protection was due primarily to
genetic factors. This work has given
rise to her current studies that are aimed at determining how such genetic
influences affect maternal vascular responses to pregnancy and fetal growth.