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Welcome to the University of Colorado School of Medicine on the Anschutz Medical Campus.

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Letter from Director John E. Repine, MD

About the Webb-Waring Center


John E. Repine, MD

Founded in 1924, the Center is named after Gerald B. Webb, MD and James J. Waring, MD.  Dr. Webb was a famous immunologist who coined the word “immunology.” Dr. Waring was a pulmonary medicine and tuberculosis specialist and the first Chairman of Medicine at the University of Colorado School of Medicine.

The Center is presently located in Research Tower 1 on the Anschutz Medical Campus in Aurora, Colorado, but will soon be on the third floor of the new Pharmacy Building.

The Center’s research is focused on fundamental investigation of the causes and consequences of inflammation, antioxidant deficiency and oxidative stress.  Oxidative stress is the common detrimental process that happens when our normal defense mechanisms are overwhelmed.  Oxidative stress is produced when we use oxygen as well as when we encounter cigarette smoke, air pollution, inflammation, exhaustive exercise, drugs, diseases and aging. Oxidative stress damages key molecules.  Damage to DNA is associated with cancer, damage to proteins leads to neurodegenerative diseases and premature aging and damage to lipids leads to atherosclerosis—a precursor of heart attacks and strokes. This central and unifying theme for the Center’s research brings all of the Center’s scientists and staff together creating a highly efficient integrated investigative team.

The Center also makes considerable effort to train students of all ages in research.  The Center has a long history of training high school, college, medical school, graduate and post-doctoral fellows as well as junior faculty in research.  The Webb-Waring Center Student Research Training Program has propelled a number of students into research careers in medicine and industry. 

While the Center is well focused on inflammation, antioxidant deficiency and oxidative stress, these fundamental processes underlie a variety of common detrimental diseases and, accordingly, Webb-Waring scientists are currently studying the causes and better ways to treat and prevent many important diseases including diabetes, the metabolic syndrome (a form of diabetes associated with aging), the acute respiratory distress syndrome (ARDS—the critical pulmonary illness that complicates infection, trauma and many other predisposing conditions), age-related macular degeneration (AMD-the leading cause of blindness in the elderly), breast cancer and many autoimmune disorders like multiple sclerosis characterized by the immune system mistakenly attacking one’s body.  The latter often results in arthritis and related inflammatory disorders.  Woven within this structure are many investigations that are relevant to aging and age-related disorders.

The Center is funded by grants from the National Institutes of Health, Juvenile Diabetes Foundation, American Diabetes Association, Ellison Medical Foundation, many prestigious foundations and a loyal group of individual donors.

 If you have any questions or any interest in our work, please contact us at 303-724-4783,  john.repine@ucdenver.edu. or John  E. Repine, MD, Waring Professor of Medicine and Pediatrics, Webb-Waring Center Director, Webb-Waring Center at the University of Colorado Denver, Box C322, 12800 East 19th Avenue, Aurora, Colorado 80045-9806

Thank you for your continued interest and meaningful support of our research.