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Dr. Medhi Fini's Laboratory

Investigating Ways to Treat Cancer


Medhi Fini, MD
Dr. Mehdi Fini, MD

Many traditional cancer drugs that are used alone to treat lung and breast cancer have produced very little improvement. Also, most anti-cancer drugs are associated with serious side effects due to their lack of selectivity for the tumor cells. These observations suggest that effective treatment of these cancers will require combination therapy. However, the use of multiple agents often increases systemic toxicity.

I am presently interested in targeted drug delivery and use of novel combinations of chemotherapy. I am focusing on learning the responsible mechanisms in order to increase the selective cytotoxicity of common cytotoxins against cancer cells while reducing their systemic toxicity. One approach uses the novel tocopheryl derivative with anti-cancer activity (Tocopheryl Succinate) as an anti-cancer agent. I am also investigating the chemopreventive efficacy of these agents in human lung and breast cancers.

We will test the chemopreventive and anti-cancer effects of different formulations and delivery methods of our drug candidates against different human lung and breast cancer cells. We will also determine if these approaches reduce any of the common side effects of the conventional cancer drugs.

 

 

Brooks M. Hybertson, PhD., Aerophase, Inc, Longmont Colorado

Omid C. Farokhzad, MD., Brigham and Women's Hospital, Harvard Medical School

Paul Bunn, MD., Medical Oncology, University of Colorado, Denver.

  1. Fini, M. A., Orchard-Webb, D., Kosmider, B., Amon, J. D., Kelland, R., Shibao, G., et al. (2008). Migratory activity of human breast cancer cells is modulated by differential expression of xanthine oxidoreductase. J Cell Biochem, 105(4), 1008-1026.
  2. Hybertson, B. M., Chung, J. H., Fini, M. A., Lee, Y. M., Allard, J. D., Hansen, B. N., et al. (2005). Aerosol-administered alpha-tocopherol attenuates lung inflammation in rats given lipopolysaccharide intratracheally. Exp Lung Res, 31(3), 283-294.
  3. Parmley, L. A., Elkins, N. D., Fini, M. A., Liu, Y. E., Repine, J. E., & Wright, R. M. (2007). Alpha-4/beta-1 and alpha-L/beta-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injury. Br J Pharmacol, 152(6), 915-929.
  4. Roberts, L. E., Fini, M. A., Derkash, N., & Wright, R. M. (2007). PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor. J Cell Biochem, 101(6), 1567-1587.
  5. Seymour, K. J., Roberts, L. E., Fini, M. A., Parmley, L. A., Oustitch, T. L., & Wright, R. M. (2006). Stress activation of mammary epithelial cell xanthine oxidoreductase is mediated by p38 MAPK and CCAAT/enhancer-binding protein-beta. J Biol Chem, 281(13), 8545-8558.
  6. Yoon-yub, P., Hybertson, B., Wright, R., Fini, M., Elkins, N., & Repine, J. (2004). Serum ferritin elevation and acute lung injury in rats subjected to hemorrhage: reduction by mepacrine treatment. Exp Lung Res, 30(7), 571-584.