M.S. - VU University of Amsterdam, The Netherlands, 1994-1999
Ph.D. - Baylor College of Medicine, Houston, TX, 1999-2004
Baylor College of Medicine, Houston, TX, 2004-2007
Epidermal morphogenesis and differentiation; Epidermal and hair follicle stem cells; Skin cancer; Ectodermal dysplasias
Development and homeostasis of the epidermis and hair follicles
Research in my laboratory is aimed at investigating the role of the transcription factor p63 in epidermal and hair follicle biology. To this end, my laboratory uses genetically engineered mice designed to either overexpress or ablate p63 from different cell types in the skin. These studies have led to the identification of critical functions for p63 in basal cells of the epidermis, including roles in proliferation and the initiation of differentiation. Further, we are currently investigating the role for p63 in hair follicle stem cells. In addition to using genetically engineered mice to investigate the role of p63 under homeostatic conditions, we are also using these mice to investigate the role of p63 under pathological conditions, including inherited skin diseases and skin cancer.
- Koster, M.I., Kim, S., Mills, A.A., DeMayo, F.J., and Roop, D.R. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 18(2):126-31, 2004.
- Koster, M.I., Lu, S.L., Wang, X.J., and Roop, D.R. Reactivation of developmentally expressed p63 isoforms accelerates tumor development and progression. Cancer Res. 66(8):3981-6, 2006.
- Koster, M.I., Dai, D., Marinari, B., Sano, Y., Costanzo, A., Karin, M., and Roop, D.R. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci USA, 104(9):3255-60, 2007.
- Koster, M.I. and Roop, D.R. Mechanisms regulating epithelial stratification. Ann Rev Cell Dev Biol., 23:93-113, 2007.
- Koster, M.I. and Roop, D.R. Sorting out the p63 signaling network. J Investig Dermatol 128(7):1617-9, 2008.
- Koster, M.I., Marinari, B., Payne, A.S., Kantaputra, P.N., Costanzo, A., and Roop, D.R. DeltaNp63 knockdown mice: a mouse model for AEC syndrome. Am J Med Genet A, 9:1942-1947, 2009.
- Kim, S., Choi, I.F., Quante, J.R.., Zhang, L., Roop, D.R., and Koster, M.I. p63 directly induces expression of Alox12, a regulator of epidermal barrier formation. Exp Dermatol, 18(12):1016-21, 2009.
- Koster, M.I. p63 in skin development and ectodermal dysplasias. J Investig Derm, 130:2352-2358, 2010.
- Mikkola, M.L., Costanzo, A., Thesleff, I., Roop, D.R., and Koster, M.I. Treasure or Artifact: A Decade of p63 Research Speaks for Itself. Cell Death Differ, 17(1):180-183, 2010.