Dr. Shellman’s Lab is interested in melanocyte biology, skin pigmentation, and photo-aging. This includes normal and abnormal melanocyte development, differentiation and regeneration, melanoma, as well as inherited and acquired pigmentation disorders. Her team aims to understand the functions of a not well characterized human pigmentation gene in skin, using a combination of models including zebrafish, 3D skin equivalent, human induced Pluripotent Stem cells, and a photographic UV model of human skin.
Dany Gaillard is a post-doc in Linda Barlow's laboratory and is interested in understanding the molecular mechanisms that control taste cell renewal in adults, specifically the role of Wnt/β-catenin signaling. He utilizes conditional drug-inducible β-catenin gain- and loss of function in mice to determine the role of β-catenin in the taste system.
The goal of my study is to identify the role of p63 in hair follicle stem cells, and to investigate the mechanism by which it regulates hair follicle stem cells. Since several skin and hair disorders are caused by defective stem cells, this study will help to better understand these inherited diseases and provide insight for their treatment.
Dr. Birlea’s research is aimed at investigating the cellular and molecular mechanisms of melanocyte repopulation in vitiligo. The goal of this work is to identify in vitiligo skin treated with UVB light the precursors of melanocyte populations along the hair follicle and interfollicular epidermis by performing studies of gene expression and immunostaining.
Dr. Payne has an interest in the development and manufacture of investigational cell-based products according to current Good Manufacturing Practices (cGMP) for humanclinical trials.
Dr. Dunnick is Director of the Patch Test Clinic, a referral center for the diagnosis of allergic contact dermatitis. She has developed a database and collected information on the most frequent positive reactions from her patients. She is actively involved in a multi center clinical trial to evaluate the safety and efficacy of using the T.R.U.E. Test system for patch testing in children.In conjunction with National Jewish, she is planning to begin a second clinical trial to evaluate using a new hand sanitizer for the treatment of hand dermatitis.
Research in the Williams laboratory is focused on the mammalian AP-2 transcription factor family. These genes have major functions in regulating many aspects of mammalian embryogenesis as well as post-ntal development. We have determined that the embryonic ectoderm serves as a major center for AP-2 function and this has led us into a broader analysis of the role of the embryonic ectoderm in controlling multiple aspects of development and cancer using mouse molecular genetic approaches